Ganna Stepanova

Absence of TIMP-1 reduces renal complement C3 response and fibrosis in type-1 diabetic mice

Ganna Stepanova, Krisztina Fazekas, Anna Manzéger, Miklós M. Mózes et autres

Abstract Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal failure characterized by progressive renal fibrosis and inflammation. We previously identified tissue inhibitor of metalloprotease-1 (TIMP-1) and complement C3 as major contributors to kidney fibrosis in mouse models with …

hu (code pays fourni par la source)

COVID-19 and dysregulated cholesterol levels in Type I and Type II diabetes: focus on the difference

Ganna Stepanova, Sayam Ghosal

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had a profound global impact on individuals with diabetes mellitus (DM). This review examines the interplay between COVID-19, cholesterol metabolism, and diabetes, focusing on the differences in lipid regulation between Type I (T1DM) …

hu (code pays fourni par la source)

Renal Epithelial Complement C3 Expression Affects Kidney Fibrosis Progression

Ganna Stepanova, Anna Manzéger, Miklos M Mozes, Gábor Kökény

Kidney fibrosis is a hallmark of chronic kidney diseases. Evidence shows that genetic variability and complement component 3 (C3) might influence tubulointerstitial fibrosis. Still, the role of renal C3 production in the epithelial-to-mesenchymal transition (EMT) and genetically determined fibrosis progression remains undiscovered. …

hu (code pays fourni par la source)

The Sigma-1 Receptor Is a Novel Target for Improving Cold Preservation in Rodent Kidney Transplants

Ádám Hosszú, Akos R. Toth, Tamás Lakat, Ganna Stepanova et autres

Kidney transplantation is the preferred treatment for patients with end-stage kidney disease. Maintaining organ viability between donation and transplantation, as well as minimizing ischemic injury, are critically important for long-term graft function and survival. Moreover, the increasing shortage of transplantable organs is …

hu (code pays fourni par la source)

#5526 COMPLEMENT C3 EXERTS DIRECT PRO-FIBROTIC EFFECTS ON KIDNEY TUBULES

Anna Manzéger, Rita Bencs, Krisztina Tajtiné Fazekas, Ganna Stepanova et autres

Abstract Background and Aims Renal complement expression has been observed in both experimental and human kidney diseases. We have previously reported massive tubular C3 expression in fibrotic TGF-beta1 transgenic mice (Nephrol Dial Transpl 2015, 30; S3:FP301). Still, little is known whether this …

hu (code pays fourni par la source)

MO612: Relationship of Renal Timp-1, Stat3 and Inflammatory Factors in Diabetes

Anna Manzéger, Krisztina Mikone, Miklos M Mozes, Ganna Stepanova et autres

Abstract BACKGROUND AND AIMS The balance of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) is disrupted in diabetic nephropathy and renal TIMP-1 overexpression is observed in both animal experimental models and human biopsies. The STAT3 transcription factor participates in several inflammatory …

hu (code pays fourni par la source)

Effect of miR-302b MicroRNA Inhibition on Chicken Primordial Germ Cell Proliferation and Apoptosis Rate

Bence Lázár, Nikolett Tokodyné Szabadi, Mahek Anand, Roland Imre Tóth et autres

The primordial germ cells (PGCs) are the precursors for both the oocytes and spermatogonia. Recently, a novel culture system was established for chicken PGCs, isolated from embryonic blood. The possibility of PGC long-term cultivation issues a new advance in germ cell preservation, …

hu, fr (code pays fourni par la source)

Biologia Futura: is ADAM 17 the reason for COVID-19 susceptibility in hyperglycemic and diabetic patients?

Ganna Stepanova

COVID-19 is a disease-causing current pandemic. It prevails in patients with pre-existing conditions such as diabetes and hypertension. Renin-angiotensin system was identified as a center of COVID-19 pathophysiology. There is a current controversy concerning the usage of ACE inhibitors and AR blockers …

hu (code pays fourni par la source)

Обшук особи за чинним КПК України: проблемні питання та шляхи удосконалення. The search for a person by the current Code of Ukraine: problems and ways of improvement

О.С. Степанов, Ganna Stepanova, M. Kulik, Oleg Anatolyevich Stepanov et autres

Степанов О.С., Степанова Г.М., Кулик М.Й. Обшук особи за чинним КПК України: проблемні питання та шляхи удосконалення / Підприємство, господарство і право. – №2/2017. – К. – С. 294-298

Studies on Specific Antigens and Morphological Changes in Mice in the Process of Development of Mazurenko and Friend Leukaemias

В. Э. Гурцевич, E. I. Jarova, Ganna Stepanova

Comparative detection of mite allergens in house dust of homes in Moscow by enzyme‐linked immunosorbent assay and acarologic analysis

Tatiana M. Zheltikova, Inna G. Ovsyannikova, Valentina B. Gervazieva, Thomas A.E. Platts‐Mills et autres

The present study revealed that 73% of surveyed apartments in Moscow whose residents included children with the atopic form of bronchial asthma and sensitization to Dermatophagoides pteronyssinus allergens were infested with the pyroglyphid mites D. pteronyssinus and D. farinae. The number of …

ru, us (code pays fourni par la source)

State of stress produced by a local load acting on a circular cylindrical shell with stepwise longitudinal changes of thickness

R. V. Modestova, A. M. Simakin, E. N. Samoilenko, Ganna Stepanova