Accès ouvert
2026
article
OpenAlex
Ganna Stepanova, Krisztina Fazekas, Anna Manzéger, Miklós M. Mózes et autres
Abstract Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal failure characterized by progressive renal fibrosis and inflammation. We previously identified tissue inhibitor of metalloprotease-1 (TIMP-1) and complement C3 as major contributors to kidney fibrosis in mouse models with …
hu
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Accès ouvert
2026
article
OpenAlex
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész et autres
BACKGROUND AND PURPOSE: Rare but severe adverse events (AEs) associated with mRNA-lipid nanoparticle (LNP) COVID-19 vaccines, such as Comirnaty, include anaphylaxis and inflammatory organ disorders, but their underlying mechanisms are poorly understood. We aimed to develop an animal model to study these …
hu, kr
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Arezoo Haghighi, Zsuzsanna O. Demeter, Anna Zsidai, Lili Lengyel et autres
BACKGROUND AND AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause small intestinal injury, which largely depends on the presence of gut bacteria and the immune responses triggered by them. While previous studies have emphasised the role of Toll-like receptor 4 (TLR4) and TLR2 …
hu, pl
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Arezoo Haghighi, András S. Tóth, Zsuzsanna O. Demeter, Barbara Hutka et autres
BACKGROUND AND AIMS: Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause small intestinal injury and dysbiosis. Although NSAID-induced dysbiosis is well-characterized and contributes to enteropathy, the changes in host-bacterial interactions during enteropathy remain largely unexplored. Here we assessed the expression pattern of six toll-like …
hu, fr, pk, nl
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Accès ouvert
2025
article
OpenAlex
Samaneh Haghighi, Arezoo Haghighi, Zoltán Zádori, Krisztián A. Kovács et autres
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic effects, although the possible COX-independent impact on the kidneys is largely unknown. Kidney damage is often associated with defective autophagy and autophagy dysregulation has been associated with kidney fibrosis and the pro-fibrotic …
hu
(code pays fourni par la source)
2025
article
OpenAlex
Gábor Kökény, Anna Manzéger, János Szebeni
Abstract Background and Aims Evidence suggests that the broad use of LNP-mRNA vaccines during COVID-19 pandemic might increase the incidence of kidney diseases, such as IgA nephropathy. However, the exact pathomechanism remains unclear. Therefore, we aimed to investigate how renal tubular epithelial …
hu
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Accès ouvert
2025
article
OpenAlex
Samaneh Haghighi, Arezoo Haghighi, Anna Manzéger, Gábor Kökény
Abstract Background and Aims Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and their chronic administration is associated with reduced renal blood flow, potentially causing papillary necrosis. Autophagy protects renal proximal tubular cells by removing damaged components and promoting cell survival under stress …
hu
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Accès ouvert
2025
erratum
OpenAlex
Gantsetseg Garmaa, Ștefania Bunduc, Tamás Kói, Péter Hegyi et autres
Text Correction [...]
hu, mn, ro, jp, it
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Accès ouvert
2025
preprint
OpenAlex
László Dézsi, Gábor Kökény, Gábor Szénási, Csaba Révész et autres
Background and Purpose Rare but serious adverse events (AEs) associated with mRNA-lipid nanoparticle (LNP) COVID-19 vaccines, such as Comirnaty and Spikevax, include acute and chronic inflammatory reactions, the mechanisms of which remain poorly understood. This study aimed to investigate these effects using …
hu, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Ganna Stepanova, Anna Manzéger, Miklós Mózes, Gábor Kökény
Kidney fibrosis is a hallmark of chronic kidney diseases. Evidence shows that genetic variability and complement component 3 (C3) might influence tubulointerstitial fibrosis. Still, the role of renal C3 production in the epithelial-to-mesenchymal transition (EMT) and genetically determined fibrosis progression remains undiscovered. …
hu
(code pays fourni par la source)
Accès ouvert
2024
review
OpenAlex
Gantsetseg Garmaa, Rita Nagy, Tamás Kói, Uyen Nguyen Do To et autres
BACKGROUND: Accurate detection of kidney damage is key to preventing renal failure, and identifying biomarkers is essential for this purpose. We aimed to assess the accuracy of miRNAs as diagnostic tools for chronic kidney disease (CKD). METHODS: We thoroughly searched five databases …
hu, mn
(code pays fourni par la source)
Accès ouvert
2024
review
OpenAlex
Gantsetseg Garmaa, Ștefania Bunduc, Tamás Kói, Péter Hegyi et autres
Chronic kidney disease (CKD) represents an increasing health burden. Evidence suggests the importance of miRNA in diagnosing CKD, yet the reports are inconsistent. This study aimed to determine novel miRNA biomarkers and potential therapeutic targets from hypothesis-free miRNA profiling studies in human …
hu, mn, ro, jp, it
(code pays fourni par la source)