Accès ouvert
2026
article
OpenAlex
Ganna Stepanova, Krisztina Fazekas, Anna Manzéger, Miklós M. Mózes et autres
Abstract Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal failure characterized by progressive renal fibrosis and inflammation. We previously identified tissue inhibitor of metalloprotease-1 (TIMP-1) and complement C3 as major contributors to kidney fibrosis in mouse models with …
hu
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Accès ouvert
2025
article
OpenAlex
Samaneh Haghighi, Arezoo Haghighi, Zoltán Zádori, Krisztián A. Kovács et autres
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for their analgesic effects, although the possible COX-independent impact on the kidneys is largely unknown. Kidney damage is often associated with defective autophagy and autophagy dysregulation has been associated with kidney fibrosis and the pro-fibrotic …
hu
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2025
article
OpenAlex
Gábor Kökény, Anna Manzéger, János Szebeni
Abstract Background and Aims Evidence suggests that the broad use of LNP-mRNA vaccines during COVID-19 pandemic might increase the incidence of kidney diseases, such as IgA nephropathy. However, the exact pathomechanism remains unclear. Therefore, we aimed to investigate how renal tubular epithelial …
hu
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Accès ouvert
2025
article
OpenAlex
Samaneh Haghighi, Arezoo Haghighi, Anna Manzéger, Gábor Kökény
Abstract Background and Aims Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used and their chronic administration is associated with reduced renal blood flow, potentially causing papillary necrosis. Autophagy protects renal proximal tubular cells by removing damaged components and promoting cell survival under stress …
hu
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Accès ouvert
2024
article
OpenAlex
Ganna Stepanova, Anna Manzéger, Miklós Mózes, Gábor Kökény
Kidney fibrosis is a hallmark of chronic kidney diseases. Evidence shows that genetic variability and complement component 3 (C3) might influence tubulointerstitial fibrosis. Still, the role of renal C3 production in the epithelial-to-mesenchymal transition (EMT) and genetically determined fibrosis progression remains undiscovered. …
hu
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Accès ouvert
2024
article
OpenAlex
Gantsetseg Garmaa, Anna Manzéger, Gábor Kökény
Abstract Background and Aims Various kidney conditions, such as acute kidney injury and fibrosis, cause dysregulation of miRNAs. TGF-β is one of the most potent inducer of epithelial-to-mesenchymal transition (EMT) and fibrosis. We recently reported increased miR-199 expression in TGF-β-induced kidney fibrosis …
hu
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Accès ouvert
2024
article
OpenAlex
Anna Manzéger, Zsofia Szakal, Gábor Kökény
Abstract Background and Aims The incidence of chronic kidney diseases increases worldwide, and kidney fibrosis is the final common pathway regardless of the etiology. TGF-β plays a crucial role in the pathogenesis, affecting pro-fibrotic genes and transcription factors. STAT3 (signal transducer and …
hu
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Accès ouvert
2023
article
OpenAlex
Anna Manzéger, Gantsetseg Garmaa, Miklós Mózes, Georg Hansmann et autres
Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects of peroxisome proliferator-activated receptor-γ (PPARγ) agonist …
hu, de
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Accès ouvert
2023
article
OpenAlex
Gantsetseg Garmaa, Anna Manzéger, Samaneh Haghighi, Gábor Kökény
The immortalized human renal proximal tubular epithelial cell line HK-2 is most commonly used to study renal cell physiology and human kidney diseases with tubulointerstitial fibrosis such as diabetic nephropathy, obstructive uropathy or allograft fibrosis. Epithelial-to-mesenchymal transition (EMT) is the main pathological …
hu
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Accès ouvert
2023
article
OpenAlex
Miklós Mózes, Gantsetseg Garmaa, Anna Manzéger, Gábor Kökény
Abstract Background and Aims The peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been shown to dampen TGF-β signaling and suppress miR-130a in VSMCs and also profibrotic miR-21-5p in the kidney. We have recently demonstrated that pioglitazone ameliorates established renal fibrosis by suppressing STAT3 …
hu
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Accès ouvert
2023
article
OpenAlex
Anna Manzéger, Rita Bencs, Krisztina Fazekas, Ganna Stepanova et autres
Abstract Background and Aims Renal complement expression has been observed in both experimental and human kidney diseases. We have previously reported massive tubular C3 expression in fibrotic TGF-beta1 transgenic mice (Nephrol Dial Transpl 2015, 30; S3:FP301). Still, little is known whether this …
hu
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Accès ouvert
2022
article
OpenAlex
Gábor Kökény, Ágnes Németh, Jeffrey B. Kopp, Weiping Chen et autres
Patients with chronic kidney disease and experimental animal models of kidney fibrosis manifest diverse progression rates. Genetic susceptibility may contribute to this diversity, but the causes remain largely unknown. We have previously described kidney fibrosis with a mild or severe phenotype in …
hu, us
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