Accès ouvert
2026
article
OpenAlex
Anna Lyytikäinen, Yasaman Shamshirgaran, Hedvig Hjerpe, Sara Cajander et autres
A subgroup of patients with severe combined immunodeficiencies (SCID) has disease-causing variants in genes involved in nonhomologous end-joining (NHEJ) repair of DNA double-strand breaks (DSBs). The most common variants among these patients are in the DCLRE1C gene coding for the Artemis protein, …
se
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Accès ouvert
2025
article
OpenAlex
Avinash Padhi, Anders Eklúnd, Clas Malmeström, Elina Erikson et autres
BACKGROUND: Severe sarcoidosis has been associated with peripheral blood (PB) total lymphopenia and high tumour necrosis factor α (TNF-α) levels, and the lymphopenia phenotype seems to respond poorly to conventional treatment. However, the mechanisms behind PB lymphopenia and its correlation with TNF-α …
se
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Accès ouvert
2023
article
OpenAlex
Patrick A. Sandoz, Kyra Kuhnigk, Edina K. Szabo, Sarah Thunberg et autres
γδ T cells play a pivotal role in protection against various types of infections and tumours, from early childhood on and throughout life. They consist of several subsets characterised by adaptive and innate-like functions, with Vγ9Vδ2 being the largest subset in human …
se, no, de
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Accès ouvert
2023
preprint
OpenAlex
Björn Önfelt, Patrick A. Sandoz, Kyra Kuhnigk, Edina Szabó et autres
Abstract Vγ9Vδ2 is the largest γδ T cell subset in human peripheral blood. These cells get activated and proliferate in response to phosphoantigens produced by infected or tumour transformed cells. Although Vγ9Vδ2 T cells have shown evidence of innate-like cytotoxicity, their modus …
se, no, de
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Accès ouvert
2022
article
OpenAlex
Elina Erikson, Mónika Ádori, Sharesta Khoenkhoen, Jingdian Zhang et autres
Mutations causing loss of the NF-κB regulator IκBNS, result in impaired development of innate-like B cells and defective plasma cell (PC) differentiation. Since productive PC differentiation requires B cell metabolic reprogramming, we sought to investigate processes important for this transition using the …
se
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Accès ouvert
2018
article
OpenAlex
Sharesta Khoenkhoen, Elina Erikson, Mónika Ádori, Julian M. Stark et autres
Impaired classical NF-κB pathway signaling causes reduced antibody responses to T-independent (TI) antigens. We investigated the potential reasons for defective TI responses in mice lacking the atypical inhibitory kappa B (IκB) protein of the NF-κB pathway, IκBNS. Analyses of the plasma cell …
se, us
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2017
article
OpenAlex
Mónika Ádori, Gabriel Kristian Pedersen, Csaba Ádori, Elina Erikson et autres
Abstract Marginal zone (MZ) B cells reside in the splenic MZ and play important roles in T cell–independent humoral immune responses against blood-borne pathogens. IκBNS-deficient bumble mice exhibit a severe reduction in the MZ B compartment but regain an MZ B population …
se, us
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Accès ouvert
2016
article
OpenAlex
Irena Zurnic, Sylvia Hütter, Ute Lehmann, Nicole Stanke et autres
Question: Foamy viruses (FV), and in particular PFV, have emerged in recent years as attractive gene therapy vector candidates.Since the lack of knowledge on molecular events in FV replication is a major hurdle for broader usage of foamy virus vectors, we aimed …
de, gb, us, fr, ch, ca, cz, be, nl
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Accès ouvert
2015
article
OpenAlex
Elina Erikson, Paul R. Wratil, Martin Frank, Ina Ambiel et autres
Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides. Here, we demonstrate that mouse Siglec-1, expressed on the surface of primary macrophages in an interferon-α-responsive …
de, sk, se, es, us, gb
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Accès ouvert
2015
article
OpenAlex
María Pino, Itziar Erkizia, Susana Benet, Elina Erikson et autres
BACKGROUND: Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture …
es, de, ch, us
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Accès ouvert
2015
article
OpenAlex
Sarah Schmidt, Kristína Schenková, Tarek Adam, Elina Erikson et autres
The deoxynucleoside triphosphate triphosphohydrolase and 3' → 5' exonuclease SAMHD1 restricts HIV-1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 mutations are associated with AGS. Little is known about the in vivo expression and functional regulation of this cellular factor. Here, …
de, be
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Accès ouvert
2012
article
OpenAlex
Nuria Izquierdo‐Useros, Maier Lorizate, Maria Carmen Puertas, Maria T. Rodriguez‐Plata et autres
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through …
es, de, ch
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