Mónika Ádori

Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex

Javier Guenaga, Mónika Ádori, Shridhar Bale, Swastik Phulera et autres

Abstract As a chronically replicating virus, HIV has evolved extreme sequence variability and effective shielding of functionally constrained spike protein determinants by host-derived glycans 1 . Broadly neutralizing antibodies, although rare, can be isolated from people living with HIV, revealing conserved envelope …

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HIV Env trimers elicit NHP apex cross-neutralizing antibodies mimicking human bNAbs

Javier Guenaga, Mónika Ádori, Shridhar Bale, Swastik Phulera et autres

As a chronically replicating virus, HIV has evolved extreme sequence variability and effective shielding of functionally constrained spike protein determinants by host-derived glycans. Broadly neutralizing antibodies (bNAbs), though rare, can be isolated from people living with HIV, revealing conserved Env sites as …

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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

Shridhar Bale, Javier Guenaga, Gabriel Ozorowski, Mónika Ádori et autres

The elicitation of cross-neutralizing antibodies to the HIV-1 envelope glycoprotein (Env) by vaccination remains a major challenge. Here, we immunized previously Env-immunized nonhuman primates with a series of near-native trimers that possessed N-glycan deletions proximal to the conserved CD4 binding site (CD4bs) …

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T cell toxicity induced by tigecycline binding to the mitochondrial ribosome

Qiuya Shao, Anas Khawaja, Nguyen Minh Duc, Vivek Singh et autres

Tetracyclines are essential bacterial protein synthesis inhibitors under continual development to combat antibiotic resistance yet suffer from unwanted side effects. Mitoribosomes - responsible for generating oxidative phosphorylation (OXPHOS) subunits - share structural similarities with bacterial machinery and may suffer from cross-reactivity. Since …

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Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

Marco Mandolesi, Hrishikesh Das, Liset de Vries, Yiqiu Yang et autres

The continued evolution of SARS-CoV-2 underscores the need to understand qualitative aspects of the humoral immune response elicited by spike immunization. Here, we combine monoclonal antibody (mAb) isolation with deep B cell receptor (BCR) repertoire sequencing of rhesus macaques immunized with prefusion-stabilized …

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Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

Marco Mandolesi, Hrishikesh Das, Liset de Vries, Yiqiu Yang et autres

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Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna et autres

Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from abnormal immune responses, how heteroplasmic mtDNA mutations affect the immune system at …

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Hepatic Innervations and Nonalcoholic Fatty Liver Disease

Mónika Ádori, Sadam H. Bhat, Roberto Gramignoli, Ismael Valladolid‐Acebes et autres

Abbreviations graphical abstract: VMN/PVN, hypothalamic ventromedial nucleus/paraventricular nucleus; VLM/VMM, ventrolateral medulla/ventromedial medulla; SMG/CG, superior mesenteric ganglion/caeliac ganglia; NTS, nucleus of the solitary tract; NG, nodose ganglion. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. Increased sympathetic (noradrenergic) nerve …

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Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

Mónika Ádori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquín Castro Dopico et autres

Lipopolysaccharide (LPS) stimulates dual receptor signaling by bridging the B cell receptor and Toll-like receptor 4 (BCR/TLR4). B cells from IκBNS-deficient bumble mice treated with LPS display reduced proliferative capacity and impaired plasma cell differentiation. To improve our understanding of the regulatory …

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IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens

Sharesta Khoenkhoen, Mónika Ádori, Darío Solís-Sayago, Juliette Soulier et autres

Mice lacking the atypical inhibitory kappa B (IκB) protein, IκBNS, a regulator of the NF-κB pathway encoded by the nfkbid gene, display impaired antibody responses to both T cell-independent (TI) and T cell-dependent (TD) antigens. To better understand the basis of these …

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Impaired plasma cell differentiation associates with increased oxidative metabolism in IκBNS-deficient B cells

Elina Erikson, Mónika Ádori, Sharesta Khoenkhoen, Jingdian Zhang et autres

Mutations causing loss of the NF-κB regulator IκBNS, result in impaired development of innate-like B cells and defective plasma cell (PC) differentiation. Since productive PC differentiation requires B cell metabolic reprogramming, we sought to investigate processes important for this transition using the …

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Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna et autres

Abstract Pathogenic mitochondrial (mt)DNA molecules can exhibit heteroplasmy in single cells and cause a range of clinical phenotypes, although their contribution to immunity is poorly understood. Here, in mice carrying heteroplasmic C5024T in mt-tRNA Ala – that impairs oxidative phosphorylation – we …

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