Jingdian Zhang

T cell toxicity induced by tigecycline binding to the mitochondrial ribosome

Qiuya Shao, Anas Khawaja, Nguyen Minh Duc, Vivek Singh et autres

Tetracyclines are essential bacterial protein synthesis inhibitors under continual development to combat antibiotic resistance yet suffer from unwanted side effects. Mitoribosomes - responsible for generating oxidative phosphorylation (OXPHOS) subunits - share structural similarities with bacterial machinery and may suffer from cross-reactivity. Since …

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Structural Basis of T Cell Toxicity Induced by Tigecycline Binding to the Mitochondrial Ribosome

Joanna Rorbach, Qiuya Shao, Anas Khawaja, Minh Nhat Nguyen et autres

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Correction: Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

Mike Aoun, Ana Coelho, Alexander Krämer, Amit Saxena et autres

In the originally published article, the figure images for Figs. 4 and S4 were accidentally swapped with Figs. 5 and S5, respectively; the legends remain unchanged.The corrected figures and their legends are shown here.In addition, figure citations and a typographical error were …

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Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna et autres

Pathogenic mutations in mitochondrial (mt) tRNA genes that compromise oxidative phosphorylation (OXPHOS) exhibit heteroplasmy and cause a range of multisyndromic conditions. Although mitochondrial disease patients are known to suffer from abnormal immune responses, how heteroplasmic mtDNA mutations affect the immune system at …

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Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

Mike Aoun, Ana Coelho, Alexander Krämer, Amit Saxena et autres

B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural autoreactive B cells (C1-B) specific for a …

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Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

Mónika Ádori, Sharesta Khoenkhoen, Jingdian Zhang, Xaquín Castro Dopico et autres

Lipopolysaccharide (LPS) stimulates dual receptor signaling by bridging the B cell receptor and Toll-like receptor 4 (BCR/TLR4). B cells from IκBNS-deficient bumble mice treated with LPS display reduced proliferative capacity and impaired plasma cell differentiation. To improve our understanding of the regulatory …

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Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria

Cristina Remeş, Anas Khawaja, Sarah F. Pearce, Adam M. Dinan et autres

The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet many molecular details of mitochondrial translation remain elusive. It has been commonly held view that translation initiation in human mitochondria proceeded in a manner similar to bacterial systems, with the …

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Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance

Lucie Rodriguez, Christian Pou, Tadepally Lakshmikanth, Jingdian Zhang et autres

Myalgic encephalomyelitis (ME) previously also known as chronic fatigue syndrome is a heterogeneous, debilitating syndrome of unknown etiology responsible for long-lasting disability in millions of patients worldwide. The most well-known symptom of ME is post-exertional malaise, but many patients also experience autonomic …

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Impaired plasma cell differentiation associates with increased oxidative metabolism in IκBNS-deficient B cells

Elina Erikson, Mónika Ádori, Sharesta Khoenkhoen, Jingdian Zhang et autres

Mutations causing loss of the NF-κB regulator IκBNS, result in impaired development of innate-like B cells and defective plasma cell (PC) differentiation. Since productive PC differentiation requires B cell metabolic reprogramming, we sought to investigate processes important for this transition using the …

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Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Jingdian Zhang, Camilla Koolmeister, Jinming Han, Roberta Filograna et autres

Abstract Pathogenic mitochondrial (mt)DNA molecules can exhibit heteroplasmy in single cells and cause a range of clinical phenotypes, although their contribution to immunity is poorly understood. Here, in mice carrying heteroplasmic C5024T in mt-tRNA Ala – that impairs oxidative phosphorylation – we …

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Achieving symptom relief in patients with Myalgic encephalomyelitis by targeting the neuro-immune interface and inducing disease tolerance

Lucie Rodriguez, Christian Pou, Tadepally Lakshmikanth, Jingdian Zhang et autres

Abstract Myalgic encephalomyelitis, ME, previously also known as chronic fatigue syndrome (CFS) is a heterogeneous, debilitating syndrome of unknown etiology responsible for long-lasting disability in millions of patients worldwide. The most well-known symptom of ME is post-exertional malaise, but many patients also …

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Maresin1 Decreased Microglial Chemotaxis and Ameliorated Inflammation Induced by Amyloid-β 42 in Neuron-Microglia Co-Culture Models

Ping Yin, Shuang Wang, Yafen Wei, Xu Wang et autres

Inflammation resolution is regulated by specialized pro-resolving lipid mediators (SPMs) and the levels of SPMs are found decreased in Alzheimer's disease (AD) brain. We have previously found that one of the SPMs, Maresin1 (MaR1), improved neuronal survival and increase microglial phagocytosis of …

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