Lingjun Zuo

Phenome-Wide Association Study of P2RX7 Identifies Schizophrenia and Mood Disorders as Primary Associated Phenotypes

Ling Zhu, Qiao Mao, Zhixiong Luo, Bin Chen (63682) et autres

Objectives: P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these as sociations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those …

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Modifications on histone tails in psychiatric disorders

Qiao Mao, Zhixiong Luo, Zongyang Yu, Bin Chen et autres

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Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes

Ling Zhu, Qiao Mao, Zhixiong Luo, Bin Chen et autres

Objectives P2RX7 has been implicated in bipolar disorder, major depressive disorder, schizophrenia, anxiety disorders, Alzheimer's disease, and Parkinson's disease. However, the specificity and comparability of these associations remain unclear. This study aimed to systematically evaluate multiple neuropsychiatric disorders to identify those most …

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Transperitoneal vs retroperitoneal laparoscopic radical nephrectomy: a double-arm, parallel-group randomized clinical trial

Junyao Liu, Bin Zhang, Peng Qi, Xiaowei Ren et autres

OBJECTIVE: To compare the outcomes of patients undergoing Retroperitoneal laparoscopic Radical nephrectomy (RLRN) and Transperitoneal laparoscopic Radical nephrectomy (TLRN). METHODS: A total of 120 patients with localized renal cell carcinoma were randomized into either RLRN or TLRN group. Mainly by comparing the …

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Optimization Design of W‐Beam‐Modified Guardrail Structure Based on the RBF Model and Anticrossing Consideration

Tangzhi Liu, Lingjun Zuo, Pan Wu, Ge Yu et autres

The frequent occurrence of secondary traffic accidents, characterized by vehicles losing control and straying into opposing lanes on highways, has emerged as a pressing concern. To address this issue, attention has been focused on the pivotal role of median guardrails as safety …

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RNA m6A methylation in psychiatric disorders.

Qiao Mao, Jessica Luo, Xinqun Luo, Xiaoyu Zhu et autres

This comprehensive review introduces the features of m6A modification and its role in neuropsychiatric disorders. The research findings suggest that m6A modifications and their regulators play a critical role in the occurrence and development of major psychiatric disorders, especially Alzheimer's disease, affecting …

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Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia.

Jing Shi, Nan Chen, Zhiren Wang, Fan Wang et autres

OBJECTIVE: ) was a common genetic basis for both nicotine dependence and schizophrenia. METHODS: and dopaminergic and GABAergic receptor genes were evaluated. RESULTS: mRNA expression. CONCLUSIONS: mRNA is abundant in human brain and could play important role in the pathogenesis of smoking …

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KTN1 Variants Underlying Putamen Gray Matter Volumes and Parkinson’s Disease

Qiao Mao, Xiaoping Wang, Bin Chen, Longhua Fan et autres

Background: Selective loss of dopaminergic neurons and diminished putamen gray matter volume (GMV) represents a central feature of Parkinson’s disease (PD). Recent studies have reported specific effects of kinectin 1 gene (KTN1) variants on the putamen GMV. Objective: To examine the relationship …

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KTN1 variants and risk for attention deficit hyperactivity disorder

Xingguang Luο, Xiaoyun Guo, Yunlong Tan, Yong Zhang et autres

Abstract Individuals with attention deficit hyperactivity disorder (ADHD) show gray matter volume (GMV) reduction in the putamen. KTN1 variants may regulate kinectin 1 expression in the putamen and influence putamen structure and function. We aim to test the hypothesis that the KTN1 …

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Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence

Xingguang Luο, Xiaoyun Guo, Xingqun Luo, Yunlong Tan et autres

Abstract The gray matter volume (GMV) of the putamen has been reported to be regulated by kinectin 1 gene (KTN1). As a hub of the dopaminergic circuit, the putamen is widely implicated in the etiological processes of substance use disorders (SUD). Here, …

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Replicated risk CACNA1C variants for major psychiatric disorders may serve as potential therapeutic targets for the shared depressive endophenotype.

Xiaoyun Guo, Yingmei Fu, Yong Zhang, Tong Wang et autres

might confer the genetic vulnerability to the shared depressive symptoms across MPDs and CACNA1C might be the therapeutic target for depressive endophenotype as well.

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Transcriptome-wide piRNA profiling in human brains for aging genetic factors.

Longhua Fan, Xiaoping Wang, Xiandong Lin, Yuping Cao et autres

OBJECTIVE: Piwi-interacting RNAs (piRNAs) represent a molecular feature shared by all nonaging biological systems, including the germline and somatic cancer stem cells, which display an indefinite renewal capacity and lifespan-stable genomic integrity and are potentially immortal. Here, we tested the hypothesis that …

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