Accès ouvert
2026
article
OpenAlex
Shihan Huo, Min Ma, Shuo Qian, Ming Zhang et autres
Abstract Whole-tissue spatial proteomics level provides critical insights into region-specific biological regulations but remains challenging. Previously, we introduced the Micro-scaffold Assisted Spatial Proteomics (MASP) concept for whole-tissue mapping. However, this prototype required substantial development in spatial resolution, practicality, and throughput for practical …
us, in
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Accès ouvert
2026
article
OpenAlex
Ying Lyu, Yalin Zhou, Xiaoyu Zhu, Muke Han et autres
BACKGROUND: Human breast milk (HBM), as the initial food for humans, is quite essential for infant development and also for health throughout the lifespan. Exosomes are bioactive components in HBM, yet their nutritional role remains poorly recognized. OBJECTIVES: This study investigates how …
cn
(code pays fourni par la source)
2026
article
OpenAlex
Cuijie Nong, Mengyuan Zhu, Weilun Zheng, Jiacheng Yang et autres
Abstract ENPP1 is emerging as a potential target for cancer immunotherapy due to its negatively regulatory effect on the STING pathway via hydrolysis of cGAMP. Herein, we report the identification and optimization of compound A25 starting from hit compound A1. A25 is …
cn
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2026
article
OpenAlex
Huibing Chi, Xiaoyu Zhu, Bingjie Xia, Junwei Shen et autres
Lipoxygenase (LOX) is widely used in the food and pharmaceutical industries, yet its industrial application has been limited by low catalytic activity and poor thermostability. Here, we employed a B-factor-guided rational design strategy to engineer Nostoc sphaeroides LOX (NsLOX). Through site-saturation and …
cn, gb
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2026
article
OpenAlex
Huibing Chi, Bingjie Xia, Junwei Shen, Qingwei Jiang et autres
The industrial potential of lipoxygenase (LOX) in food processing and pharmaceutical research is often hampered by the persistent trade-off between the enzymatic activity and thermostability. Herein, we applied the integrated computational-assisted structure-guided design of a mutant (CP-G194 V/L235T) in Nostoc sphaeroides LOX …
cn, gb
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Accès ouvert
2026
review
OpenAlex
Mingxing Wang, Wu Yun, Xiaoyu Zhu
Background/Objectives: One possible effect of mental disorders among general workers is their impact on cardiovascular health. This study aimed to investigate the relationship between mental disorders-specifically depression, anxiety, depression-anxiety, and post-traumatic stress disorder (PTSD)-and heart disease in workers. Methods: This systematic review …
cn
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Accès ouvert
2026
preprint
OpenAlex
Peng Shang, Johnson Hoang, Elise Hong, Zhaohui Geng et autres
Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is associated with multiple risk factors and involves death of the retinal pigment epithelium (RPE). We investigated how the Y402H polymorphism of Complement Factor H (CFH) and cigarette smoke extract …
us
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2025
article
OpenAlex
Cheng Chen, Xiaoyu Zhu, Yilong Yan, Yahui Li et autres
Developing on-site preliminary screening technologies for the potential PFAS alternative, GenX, in groundwater is crucial to overcoming the limitations of traditional methods and advancing environmental monitoring. Herein, a highly sensitive and selective electrochemical molecularly imprinted (E-MIP) sensor was fabricated for the preliminary …
cn
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Accès ouvert
2025
article
OpenAlex
Libo Dai, Zhang De-sheng, Songhui Wang, Xiaoyu Zhu et autres
This paper studies the trajectory tracking control problem of an autonomous underwater vehicle (AUV). A robust model predictive control (MPC) framework based on the implementation of the receding horizon is implemented to address the challenges of unknown external disturbances and model uncertainties …
us, cn
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Accès ouvert
2025
article
OpenAlex
Shuo Qian, Shichen Shen, Xiaoyu Zhu, Christina M. Tsillas et autres
Previous studies have demonstrated that mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) enhance functional recovery after cortical injury in rhesus monkeys by reducing chronic microglial inflammation, neuronal damage, and myelination deficits. However, the signaling pathways underlying these therapeutic effects remain largely unexplored. In …
us, bg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jeffrey Page, Shichen Shen, Xiaoyu Zhu, Shuo Qian et autres
The fourth leading cause of death in the US, Chronic Obstructive Pulmonary Disease (COPD) is punctuated by frequent viral and bacterial infections causing severe acute exacerbations (AECOPD) and increased mortality. In previous work we have shown that altered immune cell signaling may …
ca, us
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Accès ouvert
2025
article
OpenAlex
Peng Zhou, Xiaoyu Zhu
Dear Editor, We read with great interest the article by Zheng et al. titled “Physical Activity, Sleep, and Risk of Late-Onset Severe Mental Illness: A Prospective Cohort Study From UK Biobank.”1 This study is the first to evaluate the joint association between …
cn
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