SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study.
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Le résumé fourni par la source
Background: The study of non-hospitalised COVID-19 cases provides a context for improved understanding of the immune response to existing and new infections. Population-based cohorts provide a unique opportunity to do this in relation to rich longitudinal pre- and pan-pandemic data. The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited pregnant women in 1990-1992 and has subsequently followed participants for over 30 years. Methods: A study comprising three clinic visits was implemented, in response to the COVID-19 pandemic, amongst ALSPAC participants to measure SARS-CoV-2 specific humoral and cellular responses longitudinally. Here we present data from the first clinic in December 2020 before the start of the UK vaccination campaign and examine associations with a set of exemplar pre- and pan-pandemic health factors. Results: We observed humoral and cellular memory immune responses to SARS-CoV-2 infection in mild cases of COVID-19 up to 9 months post-infection. Symptomatic infection elicited a memory immune response of greater magnitude, though there was variation in response in both asymptomatic and symptomatic individuals. We examined health factors associated with severe COVID-19 and found that cardio-metabolomic, respiratory and immune-related health factors associate with a memory immune response of higher magnitude. For example, in older participants (mean age 58 years), higher BMI was associated with an immune memory response of greater magnitude, particularly with anti-S and anti-N binding antibodies. Conclusions: We set out to illustrate the use of cohort studies to deliver detailed immunological data and to provide example analyses of how life course health factors can be examined in relation to the immune response following a widespread and novel infection. We expanded this assessment to include longitudinally assessed traits, opening up the potential for the more common use of longitudinal population studies for the better understanding the aetiology of infection outcome.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study
- Date Crossref
- 13/06/2026
- Éditeur
- F1000 Research Ltd
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Bristol Bristol Medical School pays non établi dans la noticeUniversité ou école supérieure
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MRC Epidemiology Unit pays non établi dans la noticeStructure de recherche
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King's College London Department of Twin Research and Genetic Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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University of Cambridge Department of Applied Mathematics and Theoretical Physics pays non établi dans la noticeUniversité ou école supérieure
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At Bristol pays non établi dans la noticeOrganisation à but non lucratif
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Bristol Royal Hospital for Children Department of Paediatric Immunology and Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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School of Cellular and Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Health and Life Sciences pays non établi dans la noticeUniversité ou école supérieure
Bristol Medical School — University of Bristol, MRC Epidemiology Unit et Department of Twin Research and Genetic Epidemiology — King's College London, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.