Mathieu Desroches

Complex excitability and “flipping" of granule cells: An experimental and computational study

Joanna Danielewicz, Guillaume Girier, Anton V. Chizhov, Mathieu Desroches et autres

In response to prolonged depolarizing current steps, different classes of neurons display specific firing characteristics (i.e., excitability class), such as a regular train of action potentials with more or less adaptation, delayed responses, or bursting. In general, one or more specific ionic …

es, fr, ru (code pays fourni par la source)

Unmasking the hidden catalyst: How infections trigger Alzheimer’s disease

Tamàs Fülöp, Alan Cohen, Éric Frost, Simon Lévesque et autres

For years, the understanding of Alzheimer's disease (AD) has been shaped by the amyloid hypothesis, which suggests that pathological markers like amyloid-β (Aβ) and phosphorylated tau are the primary drivers of the disease. This hypothesis has guided the development of major treatment …

ca, us, es, fr, jp, pl (code pays fourni par la source)

Unmasking the hidden catalyst: How infections trigger Alzheimer's disease

T. Fulop, Eric Frost, Simon Lévesque, Abdelouahed Khalil et autres

For years, the understanding of Alzheimer's disease (AD) has been shaped by the amyloid hypothesis, which suggests that pathological markers like amyloid-β (Aβ) and phosphorylated tau are the primary drivers of the disease. This hypothesis has guided the development of major treatment …

ca, us, es, fr, jp, pl (code pays fourni par la source)

Depolarization block induction via slow NaV1.1 inactivation in Dravet syndrome

Louisiane Lemaire, Mathieu Desroches, Serafim Rodrigues, Fabien Campillo

1.1, a sodium channel mainly expressed in fast-spiking inhibitory neurons. Layer et al. (Front. Cell. Neurosci. 15, 2021) showed that one of these mutations alters the voltage dependence of channel activation, as well as the voltage dependence and kinetics of slow inactivation. …

fr, es (code pays fourni par la source)

Topological Data Analysis in Finsler Spaces

Nelson Leal, Danilo Barros de Souza, Serafim Rodrigues, Mathieu Desroches

We introduce a new approach to Topological Data Analysis (TDA) based on Finsler metrics and we also generalize the classical concepts of Vietoris-Rips and Cech complexes within this framework. In particular, we propose a class of directionally dependent Finsler metrics and establish …

Role of gap junctions and clustered connectivity in emergent synchronization patterns of inhibitory neuronal networks

H. Todd, Mathieu Desroches, N. Alex Cayco-Gajic, Boris Gutkin

Inhibitory interneurons, ubiquitous in the central nervous system, form networks connected through both chemical synapses and gap junctions. These networks are essential for regulating the activity of principal neurons, especially by inducing temporally patterned dynamic states. Here, we aim to understand the …

fr, es (code pays fourni par la source)

GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model

Emre Baspinar, Martina Simonti, Hadi Srour, Mathieu Desroches et autres

Cortical spreading depolarization (CSD) is a wave of depolarization with local onset and extended propagation implicated in several pathological conditions. Its mechanisms have been extensively investigated, including our recent studies showing with experimental and computational approaches that the hyperactivity of GABAergic neurons' …

fr, es, nl (code pays fourni par la source)

Biophysically inspired mean-field model of neuronal populations driven by ion exchange mechanisms

Giovanni Rabuffo, Abhirup Bandyopadhyay, Carmela Calabrese, Kashyap Gudibanda et autres

Abstract Whole-brain simulations are a valuable tool for gaining insight into the multiscale processes that regulate brain activity. Due to the complexity of the brain, it is impractical to include all microscopic details in a simulation. Hence, researchers often simulate the brain …

fr, es, fi (code pays fourni par la source)

Biophysically inspired mean-field model of neuronal populations driven by ion exchange mechanisms

Giovanni Rabuffo, Abhirup Bandyopadhyay, Carmela Calabrese, Kashyap Gudibanda et autres

Whole-brain simulations are a valuable tool for gaining insight into the multiscale processes that regulate brain activity. Due to the complexity of the brain, it is impractical to include all microscopic details in a simulation. Hence, researchers often simulate the brain as …

fr, es, fi (code pays fourni par la source)

Multiple bursting patterns in Lateral Habenula neurons: experiments and computational model

Dmitry Fedorov, Fabien Campillo, Mathieu Desroches, Edgar Soria‐Gómez et autres

Abstract The Lateral Habenula (LHb) is a small brain structure specialized in encoding aversive signals. Bursting activity in the LHb has been consistently linked to mood regulation, with increased bursting activity proposed to promote depressive behaviors. Bursting is a complex dynamic process …

es, fr (code pays fourni par la source)

Modeling impairment of ionic regulation with extended Adaptive Exponential integrate-and-fire models

Damien Depannemaecker, Federico Tesler, Mathieu Desroches, Viktor Jirsa et autres

To model the dynamics of neuron membrane excitability many models can be considered, from the most biophysically detailed to the highest level of phenomenological description. Recent works at the single neuron level have shown the importance of taking into account the evolution …

fr, es (code pays fourni par la source)

Correction: Dynamics of a Piecewise-Linear Morris–Lecar Model: Bifurcations and Spike Adding

J. Penalva, Mathieu Desroches, Antonio E. Teruel, Catalina Vich

es, fr (code pays fourni par la source)