Wei Cong

Dual-Stimuli-Responsive Nanoplatform Delivering Molecular Glue CR8 for Synergistic CDK12 Degradation and Immunomodulatory Photothermal Therapy in TNBC

Nan Zhang, Huaxing Shen, Wei Cong, Yurui Zhu et autres

The clinical translation of the molecular glue CR8, a potent CDK12/CCNK degrader for reversing TNBC immunosuppression, is severely hampered by its poor solubility and off-target toxicity. To surmount these challenges, we engineered an intelligent nanoplatform, ZCPc, for synergistic chemo-photothermal-immunotherapy. Leveraging the intrinsic …

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Decadal Meta‐Analysis Confirms Bacillus spp. Optimizes Fish Intestinal Microbiota

Qing Kun Yang, Y. Jin, Lei Yang, Renge Hu et autres

Against the backdrop of reducing the use of antibiotics in aquaculture, the application of Bacillus spp. as probiotics has gained attention. Probiotics exert a beneficial impact on health by modulating the intestinal microbiota, consequently influencing the growth and overall health status of …

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Spatiotemporally controlled protein degradation via NIR-activatable PROTAC platform

Nan Wang, Wei Cong, Yurui Zhu, Huaxing Shen et autres

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Correction to “Systematical Mutational Analysis of FRATtide against Osteoclast Differentiation by Alanine Scanning”

Yi An Yang, Chenchen Geng, Huaxing Shen, Jingru Chao et autres

[This corrects the article DOI: 10.1021/acsmedchemlett.4c00127.].

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Self-Assembled Molecular Glue Prodrug System for Enhanced Synergistic Tumor Therapy by Combining CDK12 Protein Degradation and Immunotherapy

Nan Zhang, Ruihao Li, Huaxing Shen, Li Huang et autres

Molecular glue degraders have recently emerged as a promising strategy for targeting proteins previously considered undruggable. Among these, CR8 has demonstrated potent anticancer efficacy in vitro by effectively degrading cyclin-dependent kinase 12 and cyclin K. However, its clinical application is restricted by …

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Peptide Double-Stapling and Arginine N -Glycosylation Triggered the Development of Therapeutic Antimicrobial Peptides Capable of Killing Drug-Resistant Bacteria in Mice

Xiang Li, Yanjiao Ding, Jingwen Xue, Yinxue Fu et autres

Antimicrobial peptides SAAP-148 exhibited excellent antimicrobial activities but suffered from inherent disadvantages, including cytotoxicity and poor proteolytic stability. Herein, we developed a novel strategy combining one unique silver-catalyzed solid-phase glycosylation-enabled arginine N -glycosylation strategy and all-hydrocarbon peptide double-stapling, and five-round peptide libraries …

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Tyrosinase‐Catalyzed Peptide Stapling Using Para‐Amino Phenylalanine and Tyrosine Anchoring Residues

Nan Wang, Zhengyang Xu, Huaxing Shen, Wei Cong et autres

Abstract Peptide stapling techniques have historically relied on metal‐catalyzed chemical reactions, with no examples using enzymes. Here, inspired by tyrosinase‐mediated oxidation, we describe the efficient side‐chain to side‐chain coupling of p‐amino phenylalanine (Z) and tyrosine (Y) amino acids using a commercially available …

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Tyrosinase‐Catalyzed Peptide Stapling Using Para‐Amino Phenylalanine and Tyrosine Anchoring Residues

Nan Wang, Zhengyang Xu, Huaxing Shen, Wei Cong et autres

Peptide stapling techniques have historically relied on metal-catalyzed chemical reactions, with no examples using enzymes. Here, inspired by tyrosinase-mediated oxidation, we describe the efficient side-chain to side-chain coupling of p-amino phenylalanine (Z) and tyrosine (Y) amino acids using a commercially available tyrosinase. …

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Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy (Adv. Healthcare Mater. 32/2024)

Baofeng Gong, Weicong Zhang, Wei Cong, Yuankai Gu et autres

Alzheimer's Disease Upon systemic administration of NPD via tail vein injection, NPD effectively penetrated the bloodbrain barrier and delivered proteolysis-targeting chimera (PROTAC), to the intracranial lesions. At where, PROTACs bridged TAU and KEAP1 that induced tau ubiquitination and degradation through the UPS, …

An evodiamine derivative inhibits osteoclast differentiation and protects against OVX ‐induced bone loss in mice

Chao Liu, Huaxing Shen, Huang Li, Nan Wang et autres

Evodiamine is a biologically active alkaloid extracted from the fruit of the traditional Chinese medicine Evodia rutaecarpa (Juss.) Benth. (Fructus Evodiae, Wuzhuyu). However, due to its lipophilic chemical structure, low water solubility results in poor bio-availability, which limits its broader application. 3-Amino-10-hydroxyl-evodiamine …

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A β‐Lactamase Responsive Peptide Inhibits MRSA Infection through Self‐Assembled Nanonet

Minghao Wu, Yuting Li, Huaxing Shen, Yanan Zhang et autres

Gram-positive S. aureus is one of the leading pathogens for death associated with antimicrobial resistance. The β-lactamase (Bla) secreted by methicillin-resistant S. aureus (MRSA) hydrolyzes nearly all β-lactam antibiotics, leaving only a few antibiotics available for the clinical treatment of MRSA infections. …

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Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy

Baofeng Gong, Weicong Zhang, Wei Cong, Yuankai Gu et autres

Alzheimer's disease (AD) poses a significant burden on the economy and healthcare systems worldwide. Although the pathophysiology of AD remains debatable, its progression is strongly correlated with the accumulation of tau aggregates. Therefore, tau clearance from brain lesions can be a promising …

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