Decadal Meta‐Analysis Confirms Bacillus spp. Optimizes Fish Intestinal Microbiota

Le résumé fourni par la source

Against the backdrop of reducing the use of antibiotics in aquaculture, the application of Bacillus spp. as probiotics has gained attention. Probiotics exert a beneficial impact on health by modulating the intestinal microbiota, consequently influencing the growth and overall health status of fish. However, the effectiveness of Bacillus spp. supplementation as well as the specific changes of fish intestinal microbiota following variations in the species, amounts, and feeding forms of Bacillus spp. remain unanalyzed. We collected publicly available 16S rRNA gene sequence data (2012-2022) and used meta-analysis to combine and summarize the studies that met the inclusion criteria. The results indicated that Bacillus spp. supplementation significantly increased the α-diversity indices, including the Shannon index (p = 0.041), Simpson index (p = 0.002), and Pielou evenness index (p = 0.004), but did not affect the β-diversity index (p = 0.44). The Chao1 index was significantly influenced by different Bacillus spp., forms, treatment duration, and amounts (p < 0.01). Bacillus spp. supplementation also increased the Firmicutes/Bacteroidetes ratio and enhanced the relative abundance of candidate probiotics, while reducing the relative abundance of potential pathogenic genera. These findings confirm Bacillus spp. positively regulate fish intestinal microbiota, offering evidence for their probiotic application in aquaculture.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.