Sameer Abraham

Development of an investigational epigenetic silencer therapy to transcriptionally inactivate viral DNA in chronic hepatitis B

Yesseinia I. Angleró-Rodriguez, Qiang Xiong, Martino Alfredo Cappelluti, Sarah B. Voytek et autres

Approved chronic hepatitis B therapies rarely result in functional cure, as they fail to permanently silence all transcriptionally active hepatitis B virus (HBV) DNA. CRMA-1001 employs an optimized epigenetic silencer that represses viral transcription through targeted deposition of DNA methylation on episomal …

it (code pays fourni par la source)

Unique territorial and compartmental organization of chromosomes in the holocentric silkworm

José Gil, Emily Navarrete, Clio B. Hockens, Neil Chowdhury et autres

Hallmarks of multicellular eukaryotic genome organization are chromosome territories, compartments, and loop-extrusion-mediated structures, including TADs. However, these have mainly been observed in model organisms, and most eukaryotes remain unexplored. Using Hi-C in the silkworm Bombyx mori we discover a novel chromatin folding …

fr, us (code pays fourni par la source)

Rules of engagement for condensins and cohesins guide mitotic chromosome formation

Kumiko Samejima, Johan Harmen Gibcus, Sameer Abraham, Fernanda Cisneros-Soberanis et autres

We used Hi-C, imaging, proteomics, and polymer modeling to define rules of engagement for SMC (structural maintenance of chromosomes) complexes as cells refold interphase chromatin into rod-shaped mitotic chromosomes. First, condensin disassembles interphase chromatin loop organization by evicting or displacing extrusive cohesin. …

gb, us, de, at (code pays fourni par la source)

Unique territorial and compartmental organization of chromosomes in the holocentric silkmoth

Ines Anna Drinnenberg, José Pedro Gil, Emily Navarette, Leah F. Rosin et autres

fr, us, ru (code pays fourni par la source)

OS-090 Novel epigenetic editing technology targets hepatitis B virus in vivo to deeply and durably repress viral markers

Yesseinia I. Angleró-Rodriguez, Sahar Abubucker, John Xiong, Jhon Medina et autres

Cooltools: Enabling high-resolution Hi-C analysis in Python

Nezar A. Abdennur, Sameer Abraham, Geoffrey Fudenberg, Ilya M. Flyamer et autres

Chromosome conformation capture (3C) technologies reveal the incredible complexity of genome organization. Maps of increasing size, depth, and resolution are now used to probe genome architecture across cell states, types, and organisms. Larger datasets add challenges at each step of computational analysis, …

us, ch, at (code pays fourni par la source)

Rules of engagement for condensins and cohesins guide mitotic chromosome formation

Kumiko Samejima, Johan Harmen Gibcus, Sameer Abraham, Fernanda Cisneros-Soberanis et autres

During mitosis, interphase chromatin is rapidly converted into rod-shaped mitotic chromosomes. Using Hi-C, imaging, proteomics and polymer modeling, we determine how the activity and interplay between loop-extruding SMC motors accomplishes this dramatic transition. Our work reveals rules of engagement for SMC complexes …

gb, us, de, at, bg (code pays fourni par la source)

Rules of engagement for cohesin and condensin complexes during mitotic chromosome formation

Fernanda Cisneros-Soberanis, Maria Alba Abad, Bethan Medina‐Pritchard, Arockia Jeyaprakash Arulanandam et autres

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.

Cooltools: enabling high-resolution Hi-C analysis in Python

Nezar A. Abdennur, Sameer Abraham, Geoffrey Fudenberg, Ilya M. Flyamer et autres

Abstract Chromosome conformation capture (3C) technologies reveal the incredible complexity of genome organization. Maps of increasing size, depth, and resolution are now used to probe genome architecture across cell states, types, and organisms. Larger datasets add challenges at each step of computational …

us, ch, at (code pays fourni par la source)

Systematic evaluation of chromosome conformation capture assays

Betül Akgöl Oksuz, Liyan Yang, Sameer Abraham, Sergey V. Venev et autres

us (code pays fourni par la source)

Systematic evaluation of chromosome conformation capture assays

Betül Akgöl Oksuz, Liyan Yang, Sameer Abraham, Sergey V. Venev et autres

Chromosome conformation capture (3C) assays are used to map chromatin interactions genome-wide. Chromatin interaction maps provide insights into the spatial organization of chromosomes and the mechanisms by which they fold. Hi-C and Micro-C are widely used 3C protocols that differ in key …

us (code pays fourni par la source)

Ultrastructural Details of Mammalian Chromosome Architecture

Nils Krietenstein, Sameer Abraham, Sergey V. Venev, Nezar A. Abdennur et autres

us (code pays fourni par la source)