Accès ouvert
2026
article
OpenAlex
R. Ciaran MacKenzie Frater, Rikke Rejnholdt Jensen, Joaquim Ollé López, Valentin Flury et autres
Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replication and transcription to access the DNA template without jeopardizing chromatin function. Here, we reveal a unified requirement for the histone …
dk, nl, us
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
R. Ciaran MacKenzie Frater, Rikke Rejnholdt Jensen, Joaquim Ollé López, Valentin Flury et autres
Summary Nucleosomes with their associated modifications underlie genome organisation and regulation. Replication and transcription require nucleosome disassembly to access the DNA template. How this is orchestrated without jeopardizing chromatin function remains unknown. Here, we reveal a general, global requirement of the histone …
dk, nl, us, au
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé López, Takeo Narita et autres
We present the Chromatin Landscape and Structure to Expression Regressor (CLASTER), an epigenetic-based deep neural network that can integrate different data modalities describing the chromatin landscape and its 3D structure. CLASTER effectively translates them into nascent transcription levels measured at a kilobasepair …
us, dk
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé-López, Takeo Narita et autres
Abstract We present the Chromatin Landscape and Structure to Expression Regressor (CLASTER), an epigenetic-based deep neural network that can integrate different data modalities describing the chromatin landscape and its 3D structure. CLASTER effectively translates them into nascent transcription levels measured at a …
us, dk
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé-López, Takeo Narita et autres
Abstract We present the Chromatin Landscape and Structure to Expression Regressor (CLASTER), an epigenetic-based deep neural network that can integrate different data modalities describing the chromatin landscape and its 3D structure. CLASTER effectively translates them into nascent transcription levels measured at a …
us, dk
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé-López, Takeo Narita et autres
Additional file 1. Supplementary Figures S1-S27.
us, dk
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé-López, Takeo Narita et autres
Additional file 2. Supplementary Tables S1-S8.
us, dk
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé-López, Takeo Narita et autres
Additional file 2. Supplementary Tables S1-S8.
us, dk
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Marc Pielies Avelli, Arnor Ingi Sigurdsson, Joaquim Ollé-López, Takeo Narita et autres
Additional file 1. Supplementary Figures S1-S27.
us, dk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Job Dekker, Betül Akgöl Oksuz, Yang Zhang, Ye Wang et autres
to map and analyse the 4D nucleome in widely used H1 human embryonic stem cells and immortalized fibroblasts (HFFc6). We produced and integrated diverse genomic datasets of the 4D nucleome, each contributing unique observations, which enabled us to assemble extensive catalogues of …
us, dk, de, cn, nl, pl, it
(code pays fourni par la source)
2025
article
OpenAlex
Susanne C. S. Bantele, Irene Mordini, Alva Biran, Nicolás Alcaraz et autres
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is unknown whether the surrounding chromatin is restored to its naïve state. We show that a …
dk
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Mariia Metelova, Maria Louisa Vigh, Nils Krietenstein
The regulation of cell-type-specific transcription relies on complex 3D interactions between promoters and distal regulatory elements. Although Hi-C has advanced our understanding of genome architecture, its high sequencing demand limits use in large-scale or time course experiments. We introduce Micro-C-ChIP, a strategy …
dk
(code pays fourni par la source)