Eugene M. Oltz

High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk

Valeriya Malysheva, Helen F. Ray-Jones, Nora Lakes, Rachel Anne Brown et autres

Abstract Innate lymphoid cells (ILCs) are rare tissue-resident lymphocytes that functionally mirror cells of CD4 + T helper lineage but lack antigen receptors. Type 3 ILCs (ILC3s) are enriched at barrier sites, regulating inflammation and promoting tissue integrity. Here we profile the …

be, gb, nl, us, jp (code pays fourni par la source)

High-resolution promoter interaction analysis implicates genes involved in activation of type 3 innate lymphoid cells in immune disease risk.

Valeriya Malysheva, Helen Ray-Jones, Nora Lakes, Rachel Anne Brown et autres

CRISPRi screening identifies SON and MAP4K1 as regulators of type III cytokine expression in innate lymphoid cells

Rachel Anne Brown, Andrew W. Dangel, Ankita Saini, Patrick L. Collins et autres

The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive "type III" responses that protect against extracellular pathogens, promote mucosal barrier integrity, and foster microbiota homeostasis. However, dysregulation of IL-22 and/or IL-17 contributes to autoimmunity, chronic …

us (code pays fourni par la source)

Author Correction: Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt

Bishan Bhattarai, Alina Ulezko Antonova, José Luís Fachi, Leone S. Hopkins et autres

us, br (code pays fourni par la source)

Cell type-specific enhancers regulate IL-22 expression in innate and adaptive type 3 lymphoid cells

Ankita Saini, Leone S. Hopkins, Vanida Ann Serna, Matthew V. D. McCullen et autres

IL-22, a signature cytokine for type 3 lymphoid cells, including T helper 17/22 (Th17/22) and type 3 innate lymphoid cells (ILC3), mediates epithelial homeostasis and protective pathogen responses in barrier tissues. Upon dysregulation, IL-22 can drive chronic inflammatory diseases, yet little is …

us (code pays fourni par la source)

Phosphorylation of GSK3β at Ser389 prevents thymocyte necroptosis and influences the diversity of the Tcr repertoire 4584

Felipe Valença-Pereira, Ryan M. Sheridan, Kent A. Riemondy, Tina M. Thornton et autres

Abstract Description The recombination of Tcrb and Tcra genes requires several cycles of programmed DNA double-strand breaks (DSBs) in double-negative (DN) thymocytes, along with effective repair mechanisms. However, the regulatory processes governing cell cycle checkpoints and survival pathways during this repair process …

us (code pays fourni par la source)

Differential usage of IL22 distal elements by innate and adaptive cells 3615

Ankita Saini, Vanida Ann Serna, Leone S. Hopkins, Matthew V. D. McCullen et autres

Abstract Description Antigen-presenting cells respond to microbial insults at mucosal surfaces by producing a variety of cytokines, including IL-1b and IL-23. These specific micro-environmental cues induce the expression of “type 3” effector molecules IL-22 and IL-17 from Th17 and innate lymphoid cells …

us (code pays fourni par la source)

Caspase11 modulates the adaptive immune response in SARS-CoV-2 infection through innate immune regulation 4503

Mostafa M. Eltobgy, Benjamin Matthew Segal, Eugene M. Oltz, Jacob S. Yount et autres

Abstract Description Caspase 11 is a critical component of the noncanonical inflammasome with multifaceted roles in the innate immune response, contributing to host defense against pathogens. We demonstrated that Casp11 deletion improved disease outcomes in SARS-CoV-2 infection by modulating the innate inflammatory …

us (code pays fourni par la source)

Histone demethylases KDM5A/B regulate epigenetic programming of exhausted T cells and restrain immunotherapy responses 4207

Amir Yousif, Abbey A. Saadey, Ava M. Lowin, Wing Keung Chan et autres

Abstract Description Epigenetic silencing of effector and stemness genes in exhausted CD8 T cells (TEX) poses a considerable hurdle to effective T cell immunotherapies. While de novo DNA methylation is known to enforce T cell exhaustion, the role of histone modifications in …

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Faithful modeling of terminal CD8+T cell dysfunction and epigenetic stabilization in vitro

Amir Yousif, Abbey A. Saadey, Ava M. Lowin, Ankita Saini et autres

Epigenetic scarring of terminally dysfunctional (TDysf) CD8+ T cells hinders long-term protection and response to immune checkpoint blockade during chronic infections and cancer. We developed a faithful in vitro model for CD8+ T cell terminal dysfunction as a platform to advance T …

ca, gb, us (code pays fourni par la source)

The transcriptional repressor BLIMP1 enforces TCF-1-dependent and -independent restriction of the memory fate of CD8+ T cells

Maegan K Murphy, Matthew V. D. McCullen, Joshua L. Deffenbaugh, Andy Y. Chen et autres

During differentiation of CD8 + T cells, the transcription factors TCF-1 and Blimp1 control progenitor and terminally differentiated states, respectively. Here, we examined the hierarchy and functional consequences of cross-regulation between these factors. We identified two Blimp1-bound cis -regulatory elements, Tcf7 +22kb …

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Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development

Mariam A. Salem, Christina N. Rau, Rebecca A. Glynn, Craig H. Bassing et autres

Double-strand breaks represent the most dangerous form of DNA damage, and in resting cells, these breaks are sealed via the non-homologous end joining (NHEJ) factor Ligase IV (LIG4). Excessive NHEJ may be genotoxic, necessitating multiple mechanisms to control NHEJ activity. However, a …

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