Mariam A. Salem

Age Dependent Immunopathology Drives Pneumonia-Associated Cardiac Dysfunction During Streptococcus pneumoniae Infection

Sameer Salam Matoo, Naresh Kumar, Mariam A. Salem, Alison Thomas et autres

Abstract Aging is a major risk factor for severe Streptococcus pneumoniae ( Spn ) infection and pneumonia-associated – major adverse cardiac events (PA-MACE), yet underlying mechanisms remain unclear. Using young and aged murine models, we show that aging exacerbates bacterial burden, mortality, …

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Gene Regulatory Programs of NK Cells Show That NCAM1 (CD56) and KIRs Are Controlled by Genetically Polymorphic Distal Regulatory Elements

Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma et autres

ABSTRACT Owing to their immunoprotective properties, natural killer (NK) cells are critical for the innate immune response to pathogens, as well as a new wave of cancer immunotherapy that harnesses natural cytotoxicity. We sought to study the genetic and epigenetic drivers behind …

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Author response for "Gene regulatory programs of NK cells show that NCAM1 (CD56) and KIRs are controlled by genetically polymorphic distal regulatory elements"

Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma et autres

Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8+ T cells in mice

Srijana Pokhrel, Gayathri Dileepan, Melissa R. Leonard, Robert T. Warren et autres

CD8+ virtual memory T (TVM) cells rapidly respond to infection via antigen-independent bystander effector functions. While it is recognized that TVM cells arise independently of foreign antigen encounter, the mechanisms governing their development are not fully understood. Here, we identify the Ikaros …

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Author response for "Gene regulatory programs of NK cells show that NCAM1 (CD56) and KIRs are controlled by genetically polymorphic distal regulatory elements"

Mariam A. Salem, Aditi Varkey, Matthew D. Estrada, Kruthika Sharma et autres

Transcriptional regulation of Ligase IV by an intronic regulatory element directs thymocyte development

Mariam A. Salem, Christina N. Rau, Rebecca A. Glynn, Craig H. Bassing et autres

Double-strand breaks represent the most dangerous form of DNA damage, and in resting cells, these breaks are sealed via the non-homologous end joining (NHEJ) factor Ligase IV (LIG4). Excessive NHEJ may be genotoxic, necessitating multiple mechanisms to control NHEJ activity. However, a …

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Transcriptional regulation of the non-homologous end joining gene Ligase IV by an intronic regulatory element directs thymocyte development

Patrick L. Collins, Mariam A. Salem, Craig H. Bassing, Eugene M. Oltz

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Hypoxia promotes cytolytic activity of CD8 T cells and pathogenesis in cutaneous leishmaniasis

Erin Fowler, Camila Farias Amorim, Emily D. S. Hales, Aditi Varkey et autres

Abstract Leishmaniasis is a disease caused by protozoan parasites of the genus Leishmania and the most common form of the disease is cutaneous leishmaniasis (CL). A fundamental question in CL is what regulates the development of severe disease, which is critical to …

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