Neal Gupta

JAK/STAT Inhibitors Reduce Risk of New-Onset Keloids and Hypertrophic Scars: A Multi-Center Retrospective Cohort Study

Robert Adler, Fariha Ahmed, Michael Kozlov, Navid Ashrafi et autres

BACKGROUND: Keloids and hypertrophic scars are fibroproliferative skin disorders characterized by excessive collagen deposition and high recurrence rates despite existing therapies. Emerging evidence implicates immune-mediated pathways, including Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, in their pathogenesis. However, population-level data …

Tazemetostat, an EZH2 inhibitor, in solid tumors harboring SWI/SNF alterations: a phase II basket study

Mrinal M. Gounder, Patrick Schöffski, Robin L. Jones, Silvia Stacchiotti et autres

Advanced tumors harboring SWI/SNF mutations are rare and aggressive. Often presenting in young patients, treatment options are limited. This phase II basket study (NCT02601950) assessed oral tazemetostat, an EZH2 inhibitor, at 800 mg twice daily (N = 129). Cohorts included malignant rhabdoid …

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Efficacy and Safety of Cysteamine-Isobionic Amide Complex in the Treatment of Periorbital Hyperpigmentation

Kayla Zafar, Julia Stolyar, Alexia Collins, Sharen Rivas et autres

Periorbital hyperpigmentation is a common yet challenging cosmetic concern due to the thin, vascular, and pigment-prone nature of periocular skin, as well as its multifactorial etiology. Discoloration in this area can be driven by genetics, photoaging, dermal thinning, and pigmentary disorders, making …

Isotretinoin Does Not Increase the Risk of Inflammatory Bowel Disease: A TriNetX Retrospective Cohort Analysis

Neal Gupta, Maile Ray, Ashley D. Shayya, Sandra McGinnis et autres

BACKGROUND: Background: The increasing use of long-term, low-dose isotretinoin for acne has raised concerns about a potential association with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. OBJECTIVE: To evaluate the association between isotretinoin therapy and the risk of IBD …

Evaluating the Risk of Atherosclerotic Cardiovascular Disease in Inflammatory Skin Disease: Insights From a TriNetX Cohort Study

Neal Gupta, Kayla Zafar, Jennifer P Wang, Maile Ray et autres

OBJECTIVE: Recognizing the risk of atherosclerotic cardiovascular disease (ASCVD) in patients is crucial in clinical practice. Recent studies suggest an association between inflammatory skin diseases and ASCVD. This study evaluates ASCVD risk in inflammatory skin disease patients using a standardized assessment model. …

The Role of the JAK/STAT Pathway in the Pathogenesis and Treatment of Keloids: A Systematic Review

Margaret Kabakova, David S. Bitterman, Kayla Zafar, Neal Gupta et autres

BACKGROUND: Keloid scars impact 4.5% to 16% of the population, causing pain, pruritus, and disfigurement. They are a common, recurrent complication in dermatologic surgery, with limited treatment options. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway has been implicated in …

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Elevated Atherosclerotic Cardiovascular Disease Risk in Fibrotic Skin Diseases: Insights From a TriNetX Cohort Study

Neal Gupta, Kayla Zafar, Jennifer P Wang, David S. Bitterman et autres

BACKGROUND: Identifying the risk of atherosclerotic cardiovascular disease (ASCVD) is a cornerstone of preventive medical care. Despite its significance, limited research has explored ASCVD risk in individuals with fibrotic skin diseases. This study aims to evaluate the risk of ASCVD in patients …

Increased Risk of Subcutaneous Nodules and Lipomas Following Influenza Vaccination: A Multicenter TriNetX Cohort Study

Neal Gupta, Alexia Collins, Kayla Zafar, Maile Ray et autres

BACKGROUND: Influenza vaccination represents one of the most widespread public health interventions. Localized cutaneous reactions, including nodules and pruritus, may occur rarely following vaccination, particularly when administered improperly. Our clinic observations suggest the potential development of lipomas following intramuscular vaccination. OBJECTIVE: This …

Glucagon-Like Peptide-1 Receptor Agonists Reduce Surgeries and Hospitalizations in Hidradenitis Suppurativa: A Multicenter TriNetX Cohort Study

Neal Gupta, Kayla Zafar, Paras Patel, Margaret Kabakova et autres

BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory skin condition frequently associated with type 2 diabetes mellitus and obesity. Glucagon-like peptide-1 receptor agonists have emerged as promising agents for managing type 2 diabetes mellitus due to their potent effects on glycemic control and …

The critical need for a distinct International Classification of Diseases code for keloids

David S. Bitterman, Neal Gupta, Marc L. Cohen, Daniel M. Siegel et autres

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Casdatifan (Cas) monotherapy in patients (pts) with previously treated clear cell renal cell carcinoma (ccRCC): Safety, efficacy and subgroup analysis across multiple doses from ARC-20, a phase 1 open-label study.

Toni K. Choueiri, Jae‐Lyun Lee, Jaime Rafael Merchan, Amita Patnaik et autres

441 Background: ccRCC, the most common histologic subtype of renal cancer, is universally associated with dysregulation of the VHL pathway, leading to HIF-2α accumulation and upregulation of multiple oncogenic pathways. Cas is an orally bioavailable, small-molecule HIF-2α inhibitor that potently inhibits transcription …

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The role of aryl hydrocarbon receptor agonists in the treatment of vitiligo

David S. Bitterman, Margaret Kabakova, Jennifer Y. Wang, Alexia Collins et autres

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