Evaluating the Risk of Atherosclerotic Cardiovascular Disease in Inflammatory Skin Disease: Insights From a TriNetX Cohort Study

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OBJECTIVE: Recognizing the risk of atherosclerotic cardiovascular disease (ASCVD) in patients is crucial in clinical practice. Recent studies suggest an association between inflammatory skin diseases and ASCVD. This study evaluates ASCVD risk in inflammatory skin disease patients using a standardized assessment model. METHODS: We used the TriNetX platform to analyze 10-year ASCVD risk in inflammatory skin conditions. Propensity score-matched (PSM) cohorts adjusted for confounders. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. RESULTS: Inflammatory skin diseases were associated with elevated ASCVD risk. Hidradenitis suppurativa showed the strongest association (HR 1.32; 95% CI: 1.17-1.48). Elevated risks were also noted for psoriasis (HR 1.21; 95% CI: 1.14-1.28) and atopic dermatitis (HR 1.15; 95% CI: 1.04–1.26). These risks were lower than in diabetes mellitus (HR 2.57; 95% CI: 2.52-2.63). CONCLUSION: Patients with hidradenitis suppurativa, psoriasis, and atopic dermatitis exhibit increased ASCVD risk. While lower than in diabetes mellitus, findings highlight the role of dermatologists in ASCVD risk identification and management. .

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