Kayla Zafar

Clascoterone Cream 1% is Safe and Effective for Papulopustular Rosacea: A Phase 2 Clinical Trial

Lucie Joerg, Kayla Zafar, Margaret Kabakova, Jennifer Y Wang et autres

BACKGROUND: Papulopustular rosacea (PPR) is a chronic inflammatory facial dermatosis with a need for well-tolerated and effective topical therapies. Clascoterone cream 1% is an androgen receptor inhibitor and a promising novel treatment for PPR. METHODS: In this single-center, single-arm, phase 2 pilot …

Evaluating the Safety and Efficacy of Sirolimus Topical Gel 0.2% to Treat Acanthosis Nigricans

Kayla Zafar, Margaret Kabakova, David Bitterman, Lucie Joerg et autres

BACKGROUND: There are currently no FDA-approved pharmacologic treatments for acanthosis nigricans (AN), a common dermatologic condition characterized by hyperpigmented, velvety plaques. AN disproportionately affects individuals with skin of color and is often associated with insulin resistance and obesity. There is a need …

An Investigator-Developed Regimen for Treatment and Prevention of Post-Inflammatory Hyperpigmentation in Skin of Color

Kayla Zafar, Margaret Kabakova, Lucie Joerg, Jared R. Jagdeo

BACKGROUND: There is an unmet demand for a post-inflammatory hyperpigmentation (PIH) treatment and prevention that is not only effective and accessible, but also safe to use in darker skin tones. OBJECTIVE: To evaluate the safety and efficacy of a comprehensive investigator-developed skincare …

Prospective Outcomes After 1064 nm Nd:YAG Laser Treatment of Basal Cell Carcinoma

Jusleen Ahluwalia, Amanda F. Marsch, Kayla Zafar, Sara E. Garrido et autres

BACKGROUND: Existing data on basal cell carcinoma (BCC) clearance rates are predominantly derived from histological sampling or retrospective analyses. Prospective evaluations of clinical clearance remain limited. This study prospectively assessed long-term clinical clearance and scar outcomes following treatment of BCC with a …

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Antiviral Treatment of Herpes Simplex Virus Decreases the Risk of Alzheimer's Disease and Dementia

Margaret Kabakova, Paras B Patel, David S. Bitterman, Jennifer Y. Wang et autres

BACKGROUND: Alzheimer's disease (AD) and dementia create major global health and economic burdens. Herpes simplex virus (HSV) infects over 3 billion people, and chronic infection is increasingly linked to neurodegeneration. OBJECTIVES: To evaluate whether antiviral therapy for oral, mucocutaneous, or anogenital HSV …

Efficacy and Safety of Cysteamine-Isobionic Amide Complex in the Treatment of Periorbital Hyperpigmentation

Kayla Zafar, Julia Stolyar, Alexia Collins, Sharen Rivas et autres

Periorbital hyperpigmentation is a common yet challenging cosmetic concern due to the thin, vascular, and pigment-prone nature of periocular skin, as well as its multifactorial etiology. Discoloration in this area can be driven by genetics, photoaging, dermal thinning, and pigmentary disorders, making …

Evaluating the Risk of Atherosclerotic Cardiovascular Disease in Inflammatory Skin Disease: Insights From a TriNetX Cohort Study

Neal Gupta, Kayla Zafar, Jennifer P Wang, Maile Ray et autres

OBJECTIVE: Recognizing the risk of atherosclerotic cardiovascular disease (ASCVD) in patients is crucial in clinical practice. Recent studies suggest an association between inflammatory skin diseases and ASCVD. This study evaluates ASCVD risk in inflammatory skin disease patients using a standardized assessment model. …

The Role of the JAK/STAT Pathway in the Pathogenesis and Treatment of Keloids: A Systematic Review

Margaret Kabakova, David S. Bitterman, Kayla Zafar, Neal Gupta et autres

BACKGROUND: Keloid scars impact 4.5% to 16% of the population, causing pain, pruritus, and disfigurement. They are a common, recurrent complication in dermatologic surgery, with limited treatment options. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway has been implicated in …

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Elevated Atherosclerotic Cardiovascular Disease Risk in Fibrotic Skin Diseases: Insights From a TriNetX Cohort Study

Neal Gupta, Kayla Zafar, Jennifer P Wang, David S. Bitterman et autres

BACKGROUND: Identifying the risk of atherosclerotic cardiovascular disease (ASCVD) is a cornerstone of preventive medical care. Despite its significance, limited research has explored ASCVD risk in individuals with fibrotic skin diseases. This study aims to evaluate the risk of ASCVD in patients …

Increased Risk of Subcutaneous Nodules and Lipomas Following Influenza Vaccination: A Multicenter TriNetX Cohort Study

Neal Gupta, Alexia Collins, Kayla Zafar, Maile Ray et autres

BACKGROUND: Influenza vaccination represents one of the most widespread public health interventions. Localized cutaneous reactions, including nodules and pruritus, may occur rarely following vaccination, particularly when administered improperly. Our clinic observations suggest the potential development of lipomas following intramuscular vaccination. OBJECTIVE: This …

Glucagon-Like Peptide-1 Receptor Agonists Reduce Surgeries and Hospitalizations in Hidradenitis Suppurativa: A Multicenter TriNetX Cohort Study

Neal Gupta, Kayla Zafar, Paras Patel, Margaret Kabakova et autres

BACKGROUND: Hidradenitis suppurativa is a chronic inflammatory skin condition frequently associated with type 2 diabetes mellitus and obesity. Glucagon-like peptide-1 receptor agonists have emerged as promising agents for managing type 2 diabetes mellitus due to their potent effects on glycemic control and …

Pincer Nail Deformity in an African American Patient Corrected by Fractionated Carbon Dioxide Laser

Alexia Collins, Margaret Kabakova, Kayla Zafar, Sumer Baroud et autres

Pincer nail deformity is a painful nail condition characterized by excessive transverse curvature of the nail plate that pinches the surrounding tissue. Treatments such as nail braces and surgical interventions are commonly used, however, these approaches often fall short of providing consistent, …