Stefano Casagranda

Diagnostic Accuracy of APTw and NOEw MRI Metrics for IDH Mutation and 1p/19q Codeletion Prediction in Gliomas

Capucine Cadin, Stefano Casagranda, François‐Xavier Lejeune, Marianne Golse et autres

ABSTRACT Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect–weighted (NOEw) markers showed promise for glioma characterization, by probing protein‐related tissue properties. However, their interpretation is confounded by …

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TMET-42. Fluid-suppressed APTw-CEST MRI enhances tumor-edema differentiation in malignant brain tumors

Chetan B. Dhakan, Stefano Casagranda, Miyoshi Mitsuharu, Orhan Ünal et autres

Abstract BACKGROUND Conventional Magnetic Resonance Imaging (MRI) struggles to distinguish tumor recurrence from non-neoplastic treatment-related changes (TRC) in patients with brain tumors. Amide Proton Transfer-weighted (APTw) imaging is a molecular Chemical Exchange Saturation Transfer (CEST) -based MRI technique to detect changes in …

us, fr, es, jp (code pays fourni par la source)

Noninvasive glioma stratification by multiparametric metabolic and microstructural MRI at 3T

Capucine Cadin, Mélanie Didier, Lucia Nichelli, Bertrand Mathon et autres

Motivation: Reliable, noninvasive identification of glioma subtypes is essential to optimize treatment and improve patient care. Goal(s): To identify glioma subtypes according to the 2021 WHO classification using a multiparametric MRI and MRS approach. Approach: Three-dimensional Principal Component Analysis was employed to …

Fluid-suppressed APTw and NOEw MRI as Protein-Related Biomarkers for Differentiating IDH Status in Gliomas

Stefano Casagranda, Capucine Cadin, Ottavia Dipasquale, Lucia Nichelli et autres

Motivation: Noninvasive identification of IDH status in gliomas is crucial for clinical management but remains challenging. Goal(s): To evaluate APT-weighted and NOE-weighted MRI as biomarkers for distinguishing gliomas with IDH mutations. Approach: Application of APT-weighted and NOE-weighted MRI techniques to analyze in …

Fourier Informed Native Deblurring (FIND): A Robust Solution for Blurring in pseudo-Continuous Arterial Spin Labeling (pCASL) MRI

Mauro Zucchelli, Ottavia Dipasquale, Christos Papageorgakis, Valentin Prévost et autres

Motivation: The low resolution of pCASL MRI leads to blurring effects that hinder brain tissue differentiation and reduce diagnostic accuracy, highlighting the need for an effective deblurring solution. Goal(s): Develop FIND (Fourier Informed Native Deblurring), a method to restore high-frequency image details …

Fluid-Suppressed Amide Proton Transfer-Weighted Imaging Outperforms Leakage-Corrected Dynamic Susceptibility Contrast Perfusion in Distinguishing Progression from Radionecrosis in Brain Metastases

Lucia Nichelli, Stefano Casagranda, Ottavia Dipasquale, Mehdi Bensemain et autres

Background: Differentiating brain radionecrosis (RN) from tumor progression (TP) is a persistent clinical difficulty. Here, we compared the diagnostic accuracy of leakage-corrected relative cerebral blood volume (rCBV) and fluid-suppressed amide proton transfer-weighted (APTw) imaging in distinguishing between RN and TP in metastases. …

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Amide proton transfer weighted MRI measurements yield consistent and repeatable results in patients with gliomas: a prospective test-retest study

Irada Pflüger, Aditya Rastogi, Stefano Casagranda, Christos Papageorgakis et autres

de, fr (code pays fourni par la source)

Amide proton transfer weighted signal of multiple sclerosis lesions and normal appearing white matter

Ibrahim Mohsen Khormi, Oun Al‐iedani, Stefano Casagranda, Christos Papageorgakis et autres

Motivation: Monitoring disease progression in people with relapsing-remitting multiple sclerosis (pw-RRMS) presents a substantial clinical challenge. Conventional MRI often fails to provide molecular biomarkers for pathophysiological changes like myelin protein accumulation indicative of demyelination. Goal(s): The study aimed to validate whether amide …

A new directional colormap for DTI fiber tractography and its application to bundle recognition

Mauro Zucchelli, Christos Papageorgakis, Stefano Casagranda

We propose a new tractography colormap based on the HSL model to complement the classical RGB colormap used in the field. Our colormap is based on a new feature, called "streamlines normal", an oriented vector that is computed from the tractography. The …

Theoretical justification for fluid-suppressed APTw imaging based on spillover correction principles

Maria Sedykh, Stefano Casagranda, Patrick Alexander Liebig, Christos Papageorgakis et autres

Fluid suppression has an inestimable value in improving the readability of Amide Proton Transfer weighted imaging in the neuro-oncological field, by removing contamination effects in the fluid compartments. With this work we wanted to justify the derivation of this metric and to …

The impact of motion and motion correction in dynamic glucose enhanced MRI

Patrick Marvin Lehmann, Christos Papageorgakis, Stefano Casagranda, Anina Seidemo et autres

Dynamic glucose-enhanced (DGE) MRI is a dynamic chemical exchange saturation transfer (CEST) method that can provide information about D-glucose uptake in tissue. DGE signal changes are small and so-called pseudo-DGE effects can appear as true DGE effects. In this study, we investigated …

Fluid-Suppressed APTw is more accurate than Leakage-Corrected rCBV imaging in the distinction between tumor progression and radionecrosis

Lucia Nichelli, Christos Papageorgakis, Mehdi Bensemain, Julian Jacob et autres

The distinction between radionecrosis and tumor recurrence is a common diagnostic dilemma, as current advanced multiparametric MRI protocols lack on accuracy. Fluid-Suppressed Amide Proton Transfer weighted (APTw) imaging has strong potentials in brain tumor post-therapeutic assessment. In this study we compare at …