Amide proton transfer weighted signal of multiple sclerosis lesions and normal appearing white matter

Le résumé fourni par la source

Motivation: Monitoring disease progression in people with relapsing-remitting multiple sclerosis (pw-RRMS) presents a substantial clinical challenge. Conventional MRI often fails to provide molecular biomarkers for pathophysiological changes like myelin protein accumulation indicative of demyelination. Goal(s): The study aimed to validate whether amide proton transfer weighted (APTw) imaging could be a sensitive molecular marker for detecting demyelination in MS lesions. Approach: We conducted APTw imaging at 3T on 24 pw-RRMS, evaluating the signal intensity within MS lesions compared to contralateral normal-appearing white matter (cNAWM) regions. Results: The investigation revealed a statistically significant increase in APTw signal intensity in MS lesions compared to cNAWM regions. Impact: Elevated APTw signal intensity could serve as a non-invasive molecular biomarker for demyelination, potentially aiding in the more accurate monitoring of MS disease progression and treatment efficacy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.