Fluid-suppressed APTw and NOEw MRI as Protein-Related Biomarkers for Differentiating IDH Status in Gliomas

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Motivation: Noninvasive identification of IDH status in gliomas is crucial for clinical management but remains challenging. Goal(s): To evaluate APT-weighted and NOE-weighted MRI as biomarkers for distinguishing gliomas with IDH mutations. Approach: Application of APT-weighted and NOE-weighted MRI techniques to analyze in vivo protein-related markers in 34 glioma patients on a 3T MR scanner. Results: Significant differences in fluid-suppressed APT-weighted signals allowed for effective differentiation between gliomas with and without IDH mutations. Impact: The results demonstrated the potential of fluid-suppressed APT-weighted MRI as a noninvasive method to improve diagnostic precision in predicting IDH status and optimize clinical management of gliomas.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.