Yasser A. Elnakady

Antibacterial Activity of Fresh and Autoclaved Platelet‐Rich Fibrin on Pseudomonas aeruginosa : An In Vitro Study

Ahmed Alzahrani, Shaban R. M. Sayed, Yasser Alrayyes, Saleh S. Aloraini et autres

OBJECTIVE: Platelet-rich fibrin (PRF) is widely used in oral and maxillofacial procedures for its regenerative and antimicrobial properties. Structural modifications, such as autoclaving, may enhance its usability. This study compared the antibacterial effects of fresh and autoclaved PRF against Pseudomonas aeruginosa, a …

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Photocrosslinkable Morin-loaded gelatin-g-GMA composite hydrogel for accelerating burn wound healing: in vitro and in vivo assessments

Amr Negm, Samar A. Salim, Tasneem Abed, Marwa Mosaad Shakweer et autres

studies using a THP-1-derived M1 macrophage model, showed that the Morin-loaded hydrogel formulations GH-5, GH-6, and GH-7 demonstrated a potent, concentration-dependent suppression of key M1 inflammatory mediators including nitric oxide (NO), IL-1β, and IL-6. This anti-inflammatory effect was mechanistically linked to the …

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Synthesis, Molecular Docking, and Antiproliferative Activity of C11‐Modified Cryptolepine and Norcryptolepine Analogues

Mariam Ahmed Azzam, Usama Fathy, Yasser A. Elnakady, Fathia Mahdy et autres

Abstract Natural indoloquinoline alkaloids e.g. cryptolepine and norcryptolepine have attracted considerable interest, due to their broad‐‎spectrum biological activities, particularly their anticancer properties. However, their clinical application remains limited by issues e.g. poor solubility, suboptimal bioavailability, and low selectivity toward cancer cells. To …

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Optimizing hydrogel performance composed of Japanese pagoda tree extract loaded-gelatin-sodium alginate-polyethylene oxide for biomedical applications: Influence incorporated calcium-based metal organic frameworks and zinc oxide NPs

Tasneem Abed, Shaza H. Aly, Samar A. Salim, Rana R. Haikal et autres

Égypte, sa (code pays fourni par la source)

A Benzimidazole-Based N-Heterocyclic Carbene Derivative Exhibits Potent Antiproliferative and Apoptotic Effects against Colorectal Cancer

Sarah Al-Nasser, Maha Hamadien Abdulla, Noura Sufyan Alhassan, Mansoor‐Ali Vaali‐Mohammed et autres

Background and Objectives: Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and improve the prognosis of CRC patients, investigating new therapeutic …

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A Novel N-heterocyclic Carbene Compound Exhibits Anticancer Properties by Inducing Apoptosis, Inhibiting Cell Migration, and Improving Standard Therapeutic Efficacy in Human Colorectal Cancer Cell Lines

Sarah Al-Nasser, Maha‐Hamadien Abdulla, Noura Sufyan Alhassan, Mansoor‐Ali Vaali‐Mohammed et autres

Colorectal cancer (CRC) remains a major global health issue. Although chemotherapy is the first-line treatment, its effectiveness is limited due to drug resistance developed in CRC. To overcome resistance and improve the prognosis of CRC patients, investigation for new therapeutic approaches is …

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The potential effect of Tubulysin A on autophagy in a group of cancer cell lines

Lamya Alsadhan, Yasser A. Elnakady, Badr Abdullah Aldahmash, Aisha Alqarni et autres

Cancer continues to be a prominent global threat, and current chemotherapy options often involve tubulin-targeting compounds disrupting microtubule function. Autophagy's role in cancer varies across cell types, tumor stages, and carcinogenic stimuli. Recent attention has focused on autophagy as a response to …

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Forensic analysis of mosquito blood meal digestion process and the impact of heroin opiate: determination of the post-feeding interval as a PMI estimation

Hend M. Alharbi, Yasser A. Elnakady, Badr Abdullah Aldahmash, Reem A. Alajmi et autres

Females of some mosquito species are anthropophilic, as they feed on human blood to support egg production and, hence, are forensically valuable if found at a crime scene. The present study investigated the blood meal digestion process in Culex pipiens L. both …

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Prospective mechanism of action of the tubulysin synthetic derivative (TAM 1344) in HCT116 colon cancer cell line

Aisha Alqarni, Yasser A. Elnakady, Lamya Alsadhan, Muhammad Nadeem Abbas et autres

Tubulin is still a highly valued target in cancer chemotherapy. Agents that target tubulin and microtubule dynamic are considered to be of high therapeutic potential. We conducted a study to assess the effects of TAM1344, a synthetic cytolysin that is derived from …

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Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade

Saheed O. Anifowose, Wejdan S. AL-Qahtani, Badr Abdullah Aldahmash, Florenz Sasse et autres

Bioprospecting natural products to find prominent agents for medical application is an area of scientific endeavor that has produced many clinically used bioactive compounds, including anticancer agents. These compounds come from plants, microorganisms, and marine life. They are so-called secondary metabolites that …

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Allethrin Promotes Apoptosis and Autophagy Associated with the Oxidative Stress-Related PI3K/AKT/mTOR Signaling Pathway in Developing Rat Ovaries

Maroua Jalouli, Afoua Mofti, Yasser A. Elnakady, Saber Nahdi et autres

The increased concern regarding the reduction in female fertility and the impressive numbers of women undergoing fertility treatment support the existence of environmental factors beyond inappropriate programming of developing ovaries. Among these factors are pyrethroids, which are currently some of the most …

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Synthesis and Antiproliferative Activity of Chlorinated Maprotiline Analogues

Mujeeb A. Sultan, Usama Karama, Abdulrahman Ibrahim Almansour, Kamal E.H. El-Taher et autres

Abstract A novel chlorinated tetracyclic compound 13 of the class ethanoanthracene, as analogue of maprotiline, was prepared via multistep syntheses. The tetracyclic key intermediates 4 and 5 with its [2.2.2] system were built via a Diels-Alder reaction between acrolein and 1,8-dichloroanthracene.The synthesized …

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