Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade
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Le résumé fourni par la source
Bioprospecting natural products to find prominent agents for medical application is an area of scientific endeavor that has produced many clinically used bioactive compounds, including anticancer agents. These compounds come from plants, microorganisms, and marine life. They are so-called secondary metabolites that are important for a species to survive in the hostile environment of its respective ecosystem. The kingdom of Plantae has been an important source of traditional medicine in the past and is also enormously used today as an exquisite reservoir for detecting novel bioactive compounds that are potent against hard-to-treat maladies such as cancer. Cancer therapies, especially chemotherapies, are fraught with many factors that are difficult to manage, such as drug resistance, adverse side effects, less selectivity, complexity, etc. Here, we report the results of an exploration of the databases of PubMed, Science Direct, and Google Scholar for bioactive anticancer phytochemicals published between 2010 and 2020. Our report is restricted to new compounds with strong-to-moderate bioactivity potential for which mass spectroscopic structural data are available. Each of the phytochemicals reported in this review was assigned to chemical classes with peculiar anticancer properties. In our survey, we found anticancer phytochemicals that are reported to have selective toxicity against cancer cells, to sensitize MDR cancer cells, and to have multitarget effects in several signaling pathways. Surprisingly, many of these compounds have limited follow-up studies. Detailed investigations into the synthesis of more functional derivatives, chemical genetics, and the clinical relevance of these compounds are required to achieve safer chemotherapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade
- Date Crossref
- 28/11/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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King Saud University pays non établi dans la noticeUniversité ou école supérieure
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Technische Universität Braunschweig pays non établi dans la noticeUniversité ou école supérieure
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Imam Mohammad ibn Saud Islamic University pays non établi dans la noticeUniversité ou école supérieure
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College of Science Department of Zoology pays non établi dans la noticeUniversité ou école supérieure
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Technical University of Braunschweig Institute for Pharmaceutical Biology pays non établi dans la noticeUniversité ou école supérieure
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College of Applied Medical Sciences Department of Clinical Laboratory Sciences pays non établi dans la noticeUniversité ou école supérieure
King Saud University, Technische Universität Braunschweig et Imam Mohammad ibn Saud Islamic University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.