Tony T. Huang

SLFN11 counteracts the RFWD3-PRIMPOL DNA damage tolerance axis to restrain gapped DNA synthesis in response to replication stress

Kate E. Coleman, Liana Goehring, Beáta Szeitz, David Fenyö et autres

Schlafen family member 11 (SLFN11) expression sensitizes cells to a spectrum of DNA-damaging chemotherapies. Previous studies have shown that SLFN11 is recruited to stalled replication forks in response to replication stress; however, the role of SLFN11 at stressed replication forks remains unclear. …

us (code pays fourni par la source)

Deubiquitinases cleave ubiquitin-fused ribosomal proteins and physically counteract their targeting to the UFD pathway

Stephanie Patchett, Seyed Arad Moghadasi, Ankita Shukla, Farid El Oualid et autres

In eukaryotes, each ribosomal subunit includes a ribosomal protein (RP) that is encoded as a fusion protein with ubiquitin (Ub). In yeast, each Ub-RP fusion requires processing by deubiquitylating enzymes (DUBs) to generate ribosome assembly-competent RPs and contribute to the cellular Ub …

us, nl (code pays fourni par la source)

Assessing the impact of global demographic change on the German economy

Donal Smith, Robert Grundke, Marius Bickmann, Tony T. Huang

This study uses the OECD METRO model to analyse the consequences of global demographic change and migration on the German economy. The projected shrinking of the working age population in Germany and its main trading partners decreases GDP noticeably until 2030, and …

ZC3H4 safeguards genome integrity by preventing transcription-replication conflicts at noncoding RNA loci

Yann Frey, Liana Goehring, Majd Haj, Gergely Róna et autres

The cellular networks that maintain genome stability encompass numerous pathways involved in all aspects of nucleic acid metabolism. Through bioinformatic analysis, we identified the Zinc Finger CCCH-Type Containing 4 protein (ZC3H4), a suppressor of noncoding RNA (ncRNA) production, as a pivotal player …

il, us, hu (code pays fourni par la source)

BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

Sudipta Lahiri, George L. Hamilton, Gemma Moore, Liana Goehring et autres

us (code pays fourni par la source)

KMT2C/KMT2D-dependent H3K4me1 mediates changes in DNA replication timing and origin activity during a cell fate transition

Deniz Gökbuget, Liana Goehring, Ryan M. Boileau, Kayla Lenshoek et autres

Mammalian genomes replicate in a cell-type-specific order during the S phase, correlated to transcriptional activity, histone modifications, and chromatin structure. The causal relationships between these features and DNA replication timing (RT), especially during cell fate changes, are largely unknown. Using machine learning, …

us (code pays fourni par la source)

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition

Minwoo Nam, Wenxin Xia, Hannan Mir, Alexandra E. Jerrett et autres

us (code pays fourni par la source)

The fifth international hackathon for developing computational cloud-based tools and resources for pan-structural variation and genomics

Sontosh K Deb, Divya Kalra, Jędrzej Kubica, Erik Stricker et autres

Background The goal of the Fifth Annual Baylor College of Medicine & DNAnexus Structural Variation Hackathon was to push forward the research on structural variants (SVs) by rapidly developing and deploying open-source software. The event took place in-person and virtually in August …

us, pl, mx, se, fr, ca, ch, br, gb, es, in, bd, Zimbabwe, cn (code pays fourni par la source)

Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency

Liana Goehring, Sarah Keegan, Sudipta Lahiri, Wenxin Xia et autres

BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we provide evidence that BRCA2 acts as a critical …

us (code pays fourni par la source)

Towards more sustainable growth

Donal Smith, Tony T. Huang

Hungary’s green transition has made progress but will need to accelerate to reach emission reduction targets. For a large part, emission reductions achieved so far are related to structural shifts induced by the transition to a market economy in the early 1990s. …

fr (code pays fourni par la source)

Scaling-up infrastructure investment to strengthen sustainable development in Brazil

Falilou Fall, Priscilla Fialho, Tony T. Huang

Infrastructure investment has been low in Brazil over the last decades, leaving significant gaps in all infrastructure sectors. To close these gaps, public investment will need to increase and become more effective, while additional private resources need to be mobilised. Improving strategic …

fr, au (code pays fourni par la source)

Transcription–Replication Conflicts as a Source of Genome Instability

Liana Goehring, Tony T. Huang, Duncan J. Smith

Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot simultaneously act on the same DNA sequence. Conflicts between the replication and transcription machineries (transcription-replication conflicts, or TRCs) are widespread in both prokaryotes and …

us (code pays fourni par la source)