Alexandra E. Jerrett

Glyceroneogenesis has a new PEP in its step(s)

Alexandra E. Jerrett, Nicolai R. Hathiramani, Jessica B. Spinelli

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Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation

Nicolai R. Hathiramani, Alexandra E. Jerrett, Jessica B. Spinelli

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Rhodoquinone carries electrons in the mammalian electron transport chain

Jonathan Valeros, Madison Jerome, Tenzin Tseyang, Paula Vo et autres

Ubiquinone (UQ), the only known electron carrier in the mammalian electron transport chain (ETC), preferentially delivers electrons to the terminal electron acceptor oxygen (O 2 ). In hypoxia, ubiquinol (UQH 2 ) diverts these electrons onto fumarate instead. Here, we identify rhodoquinone …

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Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition

Minwoo Nam, Wenxin Xia, Hannan Mir, Alexandra E. Jerrett et autres

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Hydrogen Peroxide Induces α-Tubulin Detyrosination and Acetylation and Impacts Breast Cancer Metastatic Phenotypes

Megan B. Stemberger, Julia A. Ju, Keyata N. Thompson, Trevor J. Mathias et autres

Levels of hydrogen peroxide are highly elevated in the breast tumor microenvironment compared to normal tissue. Production of hydrogen peroxide is implicated in the mechanism of action of many anticancer therapies. Several lines of evidence suggest hydrogen peroxide mediates breast carcinogenesis and …

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