Mingfeng Yang

Structural and diffusion MRI markers of the choroid plexus and perivascular regions are associated with Alzheimer’s disease pathology and cognition

Qiang Wang, Ben Chen, Qixuan Chen, Zhidai Xiao et autres

Abstract Background Choroid plexus (ChP) morphology and periventricular diffusion alterations have been implicated in Alzheimer’s disease (AD). However, whether ChP volume and the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provide complementary glymphatic-related MRI information, and whether their associations …

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Letter to the Editor: What Counts as Deterioration? A Haematology‐Informed Approach to Patient‐Initiated Escalation

Mingfeng Yang, Jianhong Wang

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Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation

Yanxin Shao, Lina Feng, Yanchun Li, Yichen Cai et autres

BACKGROUND: Ischemic stroke (IS), the main stroke type, causes neuronal injury via hypoperfusion and hypoxia, imposes heavy health burdens, and is characterized by neurological deficits driven by oxidative stress and inflammation. METHODS: A rat model of IS was established via middle cerebral …

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Olfactory radiomics signatures link pTau217 to cognitive impairment in probable Alzheimer’s disease: a multi-cohort machine learning study

Ben Chen, Pengbo Gao, Huanmin Liu, Danyan Xu et autres

BACKGROUND: Alzheimer's disease (AD) diagnosis remains challenging because current molecular biomarkers, though sensitive, lack spatial specificity. Radiomics offers a promising alternative by quantifying subtle microstructural alterations from routine MRI that are invisible to traditional volumetric analyses. Given that olfactory-related regions are preferentially …

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Sex-Specific regional brain activity and cognitive function in mild cognitive impairment: An rs-fMRI study

Qin Liu, Ben Chen, Ting Su, Qiang Wang et autres

Mild cognitive impairment (MCI) is widely recognized as an early stage of dementia. Epidemiological studies suggest that MCI is more prevalent in females than in males. Notably, there are sex differences in MCI-related brain changes. Resting-state functional magnetic resonance imaging (rs-fMRI) offers …

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Altered temporal dynamics of intrinsic brain activity in mild cognitive impairment with olfactory dysfunction

Xuanzi Li, Xiangzhu Zeng, Jiafu Li, Youxuan Zheng et autres

Background Odor identification (OI) impairment in mild cognitive impairment (MCI) elevates the risk for Alzheimer's disease (AD). The present study was designed to clarify the underlying neural mechanisms by investigating brain network aberrations in MCI patients with OI impairment using dynamic resting-state …

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Differential effects of PSEN1 mutations (p.P117L with ataxia and p.P264L without ataxia) in early-onset Alzheimer's disease

Pengbo Gao, Ben Chen, Danyan Xu, Qiang Wang et autres

Presenilin 1 (PSEN1) plays a pivotal role in early-onset Alzheimer's disease (EOAD). The clinical phenotype of EOAD is typically marked by cognitive decline, with ataxia rarely reported. We identified mutations at different positions of PSEN1 in two Chinese patients with EOAD. Interestingly, …

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Increased α-HBDH levels exacerbate the detrimental effects of Aβ and tau pathology on cognitive function in Alzheimer's disease

Huarong Zhou, Qixuan Chen, Q Wang, Ben Chen et autres

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Identification, evolution, and expression analysis of the PEBP gene family in tobacco (Nicotiana tabacum) and its role in flowering regulation via interaction with 14-3-3 proteins

Xinghui Liu, Zhibo Zi, Mingming Sun, Wenxin Xie et autres

The phosphatidylethanolamine-binding protein (PEBP) gene family plays a crucial role in regulating key biological processes in plants, such as flowering time, morphological architecture, and seed germination. However, the diversity, expression patterns, and functions of PEBP genes in Nicotiana tabacum remain largely unexplored. …

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Altered dynamic functional connectivity of orbitofrontal cortex underlies olfactory and cognitive impairment in late-life depression

Ben Chen, Shuang Liang, Ting Su, Youxuan Zheng et autres

Abstract Background Late-life depression (LLD) and odor identification (OI) dysfunction are risk factors for dementia, but the underlying neural mechanisms remain unclear. This study investigated dynamic functional connectivity (dFC) in olfactory brain regions of LLD patients with and without OI dysfunction and …

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Association and interaction of blood homocysteine and p‐tau217 levels with temporal cortical thinning and cognitive impairment in Alzheimer's disease

Qiang Wang, Xiaomei Zhong, Pengbo Gao, Zhidai Xiao et autres

INTRODUCTION: The relationships between blood homocysteine (Hcy), amyloid beta (Aβ), tau pathology, and their combined effects on cortical thinning and cognitive impairment in Alzheimer's disease (AD) remain poorly understood. METHODS: Participants were stratified into Aβ+ and Aβ- groups by positron emission tomography. …

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Sex-specific habenular dysconnectivity in patients with late-life depression

Ting Su, Ben Chen, Qin Liu, Yunheng Chen et autres

There are significant sex differences in the prevalence, symptom presentation, treatment response and brain abnormalities of patients with late-life depression (LLD). The functional connectivity of the habenula has been associated with depressive symptoms and cognitive impairments in patients with LLD. However, sex …

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