Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation
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Le résumé fourni par la source
BACKGROUND: Ischemic stroke (IS), the main stroke type, causes neuronal injury via hypoperfusion and hypoxia, imposes heavy health burdens, and is characterized by neurological deficits driven by oxidative stress and inflammation. METHODS: A rat model of IS was established via middle cerebral artery occlusion (MCAO). Sensorimotor and cognitive dysfunctions post-IS were assessed using neurological function scoring, the rotarod test, the adhesive removal test, the foot-fault test, and the Morris water maze (MWM) test. Brain injury was evaluated by TTC staining, immunofluorescence staining, and Western blotting. For mechanistic exploration, RNA transcriptome sequencing analysis, immunofluorescence staining, and ELISA were employed to determine UA's effects on oxidative stress and neuroinflammation following IS. RESULTS: UA treatment was confirmed to exert neuroprotective effects against ischemic stroke, as it can inhibit neuronal injury and improve sensorimotor and cognitive functions in rats. Mechanistically, UA upregulates the expression of Nrf2/HO-1, thereby enhancing antioxidant capacity characterized by increased levels of antioxidant enzymes (SOD, GSH, GSH-Px) and decreased level of the lipid peroxidation marker MDA. Additionally, UA suppresses neuroinflammation, which is manifested by reduced levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and elevated level of the anti-inflammatory cytokine IL-10. RNA transcriptome sequencing analysis further revealed that these neuroprotective effects of UA may be associated with inhibition of pathological NF-κB activation. CONCLUSION: Urolithin A may exert neuroprotective effects against ischemic stroke by inhibiting oxidative stress and neuroinflammation. Collectively, this study provides theoretical support for the clinical translation of UA as a poststroke neuroprotective agent.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation
- Date Crossref
- 01/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Affiliated Hospital of Shandong Academy of Medical Sciences pays non établi dans la noticeÉtablissement de santé
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Shandong First Medical University pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Pulmonary Hospital pays non établi dans la noticeÉtablissement de santé
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Qiqihar Medical University pays non établi dans la noticeUniversité ou école supérieure
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Fudan University The National Clinical Research Center for Aging and Medicine pays non établi dans la noticeUniversité ou école supérieure
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Zhongshan Hospital pays non établi dans la noticeÉtablissement de santé
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School of Medicine Tongji University Shanghai China Department of Anesthesiology pays non établi dans la noticeUniversité ou école supérieure
Affiliated Hospital of Shandong Academy of Medical Sciences, Shandong First Medical University et Shanghai Pulmonary Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.