Sex-Specific regional brain activity and cognitive function in mild cognitive impairment: An rs-fMRI study
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Le résumé fourni par la source
Mild cognitive impairment (MCI) is widely recognized as an early stage of dementia. Epidemiological studies suggest that MCI is more prevalent in females than in males. Notably, there are sex differences in MCI-related brain changes. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a valuable method for assessing brain activity during rest. This study aims to explore sex-specific regional brain activity in participants with MCI during resting states. 86 MCI participants (21 males and 65 females) and 107 normal controls (NCs) (38 males and 69 females) were included in the present study. Regional homogeneity (ReHo), degree centrality (DC), amplitude of low frequency fluctuations (ALFF), and fractional ALFF (fALFF) were used to assess brain activity. MCI females showed increased ReHo values in the right cerebellum inferior compared to NC females and MCI males. However, MCI males exhibited increased ReHo values in the left hippocampus compared to NC males and MCI females. ReHo values in the right cerebellum inferior were associated with visuospatial skills in MCI males, and language function in MCI females. Additionally, ReHo values in the left hippocampus were associated with attention function in MCI females but not in MCI males. In MCI participants, sex moderated the relationship between ReHo values in the right cerebellum inferior and cognitive function (visuospatial skills and language function), as well as the association between ReHo values in the left hippocampus and attention function. In conclusions, this study revealed sex differences in ReHo of right inferior cerebellum and left hippocampus in MCI, and the association between ReHo and cognitive impairment in MCI differs by sex. These sex-specific patterns of regional brain activity can aid in the development of sex-specific precision medicine.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Sex-Specific regional brain activity and cognitive function in mild cognitive impairment: An rs-fMRI study
- Date Crossref
- 06/04/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangdong 999 Brain Hospital pays non établi dans la noticeÉtablissement de santé
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Guangzhou Medical University The Affiliated Brain Hospital pays non établi dans la noticeUniversité ou école supérieure
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Guangzhou Psychiatric Hospital pays non établi dans la noticeÉtablissement de santé
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Southern Medical University pays non établi dans la noticeUniversité ou école supérieure
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South China University of Technology pays non établi dans la noticeUniversité ou école supérieure
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Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders pays non établi dans la noticeStructure de recherche
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The First School of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
Guangdong 999 Brain Hospital, The Affiliated Brain Hospital — Guangzhou Medical University et Guangzhou Psychiatric Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.