Gaonan Wang

Ugi-Type Reaction Enables Access to Fused Imidazole Derivatives for DNA-Encoded Library Technology

Hao Guo, Zitao Li, Gaonan Wang, Biyu Zhang et autres

This study presents a DNA-compatible synthesis of diverse N-fused imidazopyridines via a catalyst-free Ugi-type multicomponent reaction using TMSCN as a functional isonitrile equivalent. The desilylation activation occurs efficiently in water without additional catalysts. The method exhibits a broad substrate scope for aldehydes …

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DNA-Compatible Huisgen [3 + 2] Cycloaddition of In Situ Formed Nitrile Oxides with Alkenes or Alkynes to Synthesize Isoxazolines or Isoxazoles

Gaonan Wang, Xiaona Zhang, Hui Zhu, Xiaodong Shi et autres

DNA-encoded chemical library (DECL) technology is recognized as a robust screening platform for drug discovery. Developing new DNA-compatible reactions is crucial for expanding the chemical space of DECLs. Cyclization reactions, particularly those involving the formation of heterocycles, offer unique and efficient methods …

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DNA-Compatible Cyclization Reaction to Access 1,3,4-Oxadiazoles and 1,2,4-Triazoles

Gaonan Wang, Yu Tan, Hanzhi Zou, Xihang Sui et autres

DNA-encoded chemical library (DECL) technology is a commonly employed screening platform in both the pharmaceutical industry and academia. To expand the chemical space of DECLs, new and robust DNA-compatible reactions are sought after. In particular, DNA-compatible cyclization reactions are highly valued, as …

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DNA-Encoded Macrocyclic Peptide Libraries Enable the Discovery of a Neutral MDM2–p53 Inhibitor

Anthony P. Silvestri, Qi Zhang, Yan Ping, Erik W. Muir et autres

Synthetic macrocyclic peptides are an emerging molecular class for both targeting intracellular protein–protein interactions (PPIs) and providing an oral modality for drug targets typically addressed by biologics. Display technologies, such as mRNA and phage display, often yield peptides that are too large …

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Nickel-Catalyzed β-Regioselective Amination/Cyclization of Ynamide-Nitriles with Amines: Synthesis of Functionalized 3-Aminoindoles and 4-Aminoisoquinolines

Xin Xie, Yi Gan, Gaonan Wang, Yuanhong Liu

A highly regioselective nickel/Lewis acid catalyzed amination/cyclization of ynamide-nitriles with amines involving β-addition has been developed. The reaction offers an attractive and efficient route for the synthesis of 3-aminoindoles and 4-aminoisoquinoline derivatives. The Ts-group on the ynamide acts as a directing group …

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CCDC 1952960: Experimental Crystal Structure Determination

Chunxiang Qin, Xin Xie, Gaonan Wang, Xueshun Jia et autres

CCDC 1952957: Experimental Crystal Structure Determination

Chunxiang Qin, Xin Xie, Gaonan Wang, Xueshun Jia et autres

CCDC 1952958: Experimental Crystal Structure Determination

Chunxiang Qin, Xin Xie, Gaonan Wang, Xueshun Jia et autres

CCDC 1952959: Experimental Crystal Structure Determination

Chunxiang Qin, Xin Xie, Gaonan Wang, Xueshun Jia et autres

Synthesis of phospholes and 1,1′-biphospholes mediated by zirconacyclopentadienes and PBr3

Chunxiang Qin, Xin Xie, Gaonan Wang, Xueshun Jia et autres

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Nickel-catalyzed highly regioselective hydrocyanation of alkenes with Zn(CN) 2

Gaonan Wang, Xin Xie, Wei Xu, Yuanhong Liu

The first general and regioselective nickel-catalyzed hydrocyanation of terminal alkenes with Zn(CN) 2 using an air-stable and inexpensive nickel( ii ) salt as the precatalyst has been developed.

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Ligandless nickel-catalyzed transfer hydrogenation of alkenes and alkynes using water as the hydrogen donor

Gaonan Wang, Chunxiang Qin, Xin Xie, Chunli Zhang et autres

The first general route for nickel-catalyzed transfer hydrogenation reaction of alkenes and alkynes using water as the hydrogen source has been developed.

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