Paulina Soto

In vitro generation of highly infectious recombinant prions adopting structural architectures of bona fide prions

Claudio A. Soto, Fei Wang, Victor Banerjee, Carla Barria Loaiza et autres

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Distribution of chronic wasting disease (CWD) prions in tissues from experimentally exposed coyotes (Canis latrans)

Nancy Tseng Ho, Reece McGinn, Paulina Soto, Terry R. Spraker et autres

Cervids susceptible to chronic wasting disease (CWD) are sympatric with multiple other animal species that can interact with infectious prions. Several reports have described the susceptibility of other species to CWD prions, or their potential to transport them. One of these species …

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Marine mammals as sentinels of One Health

Galaxia Cortés-Hinojosa, Irene Peña-Galindo, Roberto E. Lagos, S. Navarrete et autres

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Potential impact of parasites in the transmission of chronic wasting disease

Paulina Soto, Rodrigo A.V. Morales

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Chronic wasting disease (CWD) prion detection in environmental and biological samples from a taxidermy site and nursing facility, and instruments used in surveillance activities

Paulina Soto, Nancy Tseng Ho, Mitch A. Lockwood, Austin Stolte et autres

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Detection of Chronic Wasting Disease Prions in Raw, Processed, and Cooked Elk Meat, Texas, USA

Rebeca Benavente, Fraser Brydon, Francisca Bravo‐Risi, Paulina Soto et autres

We describe chronic wasting disease (CWD) prion detection in raw and cooked meat from a CWD-positive elk. We found limited zoonotic potential in CWD prions from those meat products. Nonetheless, risk for transmission to humans is still unclear, and monitoring of circulating …

Advancements in Chronic Wasting Disease (CWD) Prion Detection: Moving Beyond the Gold Standards

Paulina Soto, Reece McGinn, Rodrigo A.V. Morales

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Detection of Prions in Wild Pigs (Sus scrofa) from Areas with Reported Chronic Wasting Disease Cases, United States

Paulina Soto, Francisca Bravo‐Risi, Rebeca Benavente, Tucker H. Stimming et autres

Using a prion amplification assay, we identified prions in tissues from wild pigs (Sus scrofa) living in areas of the United States with variable chronic wasting disease (CWD) epidemiology. Our findings indicate that scavenging swine could play a role in disseminating CWD …

Nasal bots carry relevant titers of CWD prions in naturally infected white-tailed deer

Paulina Soto, Francisca Bravo‐Risi, Carlos Kramm, Nazaret Gamez et autres

Chronic wasting disease (CWD) is a prion disease affecting farmed and free-ranging cervids. CWD is rapidly expanding across North America and its mechanisms of transmission are not completely understood. Considering that cervids are commonly afflicted by nasal bot flies, we tested the …

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Dynamics of CWD prion detection in feces and blood from naturally infected white-tailed deer

Francisca Bravo‐Risi, Paulina Soto, Rebeca Benavente, Tracy A. Nichols et autres

Chronic wasting disease (CWD) is a prion disease affecting cervids. Confirmatory testing of CWD is currently performed postmortem in obex and lymphoid tissues. Extensive evidence demonstrates the presence of infectious prions in feces of CWD-infected deer using in vitro prion-amplification techniques and …

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Plants as vectors for environmental prion transmission

Christina M. Carlson, Samuel Thomas, Matthew W Keating, Paulina Soto et autres

Prions cause fatal neurodegenerative diseases and exhibit remarkable durability, which engenders a wide array of potential exposure scenarios. In chronic wasting disease of deer, elk, moose, and reindeer and in scrapie of sheep and goats, prions are transmitted via environmental routes and …

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Identification of chronic wasting disease prions in decaying tongue tissues from exhumed white-tailed deer

Paulina Soto, Francisca Bravo‐Risi, Rebeca Benavente, Stuart Siegfried Lichtenberg et autres

Chronic wasting disease (CWD) prions cause fatal neuropathies in farmed and free-ranging cervids. The deposition of prions in natural and humanmade environmental components has been implicated as a major mechanism mediating CWD spread in wild and captive populations. Prions can be deposited …

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