Tracy A. Nichols

Accurate genomic predictions for chronic wasting disease in North American elk

C.M. Seabury, Eric K. Bhattarai, Marcel Brun, Charles D. Johnson et autres

The geographic expansion of chronic wasting disease (CWD) in North American elk (Cervus canadensis) has not been well mitigated by traditional best management practices, diagnostic surveillance, and depopulation of positive herds. Using a custom Affymetrix Axiom genetic variant array, we demonstrate that …

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Data from: Accurate genomic predictions for chronic wasting disease in North American elk

Christopher Seabury, Eric Bhattarai, Marcel Brun, Charles Johnson et autres

The geographic expansion of chronic wasting disease (CWD) in North American elk (Cervus canadensis) has not been well-mitigated by best management practices, diagnostic surveillance, and depopulation of positive herds. Using a custom Affymetrix Axiom® genetic variant array, we demonstrate that differential susceptibility …

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Distribution of chronic wasting disease (CWD) prions in tissues from experimentally exposed coyotes (Canis latrans)

Nancy T. Ho, Reece McGinn, Paulina Soto, Terry R. Spraker et autres

Cervids susceptible to chronic wasting disease (CWD) are sympatric with multiple other animal species that can interact with infectious prions. Several reports have described the susceptibility of other species to CWD prions, or their potential to transport them. One of these species …

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Detection of Prions in Wild Pigs (Sus scrofa) from Areas with Reported Chronic Wasting Disease Cases, United States

Paulina Soto, Francisca Bravo‐Risi, Rebeca Benavente, Tucker H. Stimming et autres

Using a prion amplification assay, we identified prions in tissues from wild pigs (Sus scrofa) living in areas of the United States with variable chronic wasting disease (CWD) epidemiology. Our findings indicate that scavenging swine could play a role in disseminating CWD …

Validation of a real-time quaking-induced conversion (RT-QuIC) assay protocol to detect chronic wasting disease using rectal mucosa of naturally infected, pre-clinical white-tailed deer (Odocoileus virginianus)

Robert B. Piel, Susan E. Veneziano, Eric M. Nicholson, Daniel P. Walsh et autres

Chronic wasting disease (CWD) is a fatal prion disease of cervids spreading across North America. More effective mitigation efforts may require expansion of the available toolkit to include new methods that provide earlier antemortem detection, higher throughput, and less expense than current …

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Prospective fecal microbiomic biomarkers for chronic wasting disease

Adam Didier, Maureen Bourner, Guy Kleks, Avihai Zolty et autres

Chronic wasting disease (CWD) is a naturally occurring prion disease in cervids that has been rapidly proliferating in the United States. Here, we investigated a potential link between CWD infection and gut microbiome by analyzing 50 fecal samples obtained from CWD-positive animals …

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Nasal bots carry relevant titers of CWD prions in naturally infected white-tailed deer

Paulina Soto, Francisca Bravo‐Risi, Carlos Kramm, Nazaret Gamez et autres

Chronic wasting disease (CWD) is a prion disease affecting farmed and free-ranging cervids. CWD is rapidly expanding across North America and its mechanisms of transmission are not completely understood. Considering that cervids are commonly afflicted by nasal bot flies, we tested the …

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Dynamics of CWD prion detection in feces and blood from naturally infected white-tailed deer

Francisca Bravo‐Risi, Paulina Soto, Rebeca Benavente, Tracy A. Nichols et autres

Chronic wasting disease (CWD) is a prion disease affecting cervids. Confirmatory testing of CWD is currently performed postmortem in obex and lymphoid tissues. Extensive evidence demonstrates the presence of infectious prions in feces of CWD-infected deer using in vitro prion-amplification techniques and …

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Prospective Fecal Microbiomics Biomarkers for Chronic Wasting Disease

Adam Didier, Maureen Bourner, Guy Kleks, Avihai Zolty et autres

Abstract Chronic wasting disease (CWD) is a naturally occurring prion disease in cervids that has been rapidly proliferating in the US. Here we investigated a potential link between CWD infection and gut microbiome by analyzing 50 fecal samples obtained from CWD-positive animals …

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Tonsil biopsy to detect chronic wasting disease in white-tailed deer (Odocoileus virginianus) by immunohistochemistry

David A. Schneider, Aaron D. Lehmkuhl, Terry R. Spraker, Robert O. Dittmar et autres

Chronic wasting disease (CWD) continues to spread in wild and farmed cervid populations. Early antemortem CWD testing of farmed cervids is of considerable interest to producers and regulatory agencies as a tool to combat this spread. The tissues accessible for antemortem sampling …

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Canine detection of chronic wasting disease (CWD) in laboratory and field settings

Amritha Mallikarjun, Ben Swartz, Sarah A. Kane, Michelle Gibison et autres

). Due to the long incubation period and variability of clinical signs, CWD can expand and spread to new areas before they reach diagnostically detectable levels. Antemortem testing methods currently available can be difficult to obtain and to be applied to the …

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Detection of chronic wasting disease in feces and recto-anal mucosal associated lymphoid tissues with RT-QuIC in a naturally infected farmed white-tailed deer herd

Deepanker Tewari, Melinda Fasnacht, Margaret Ritzman, Julia Livengood et autres

Chronic wasting disease (CWD) is an infectious prion disease affecting the cervids, including white-tailed deer (WTD) (Odocoileus virginianus). CWD is typically diagnosed postmortem in farmed cervids by immunohistochemistry (IHC). Amplification-based detection methods are newer generation tests currently being evaluated to improve the …

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