Mary Bee Eng Chan‐Park

Ring-Strain-Driven One-Shot Synthesis of Glycosylated Cationic Block β-Peptides with Improved In Vivo Pharmacokinetics and Biodistribution

Zhangyong Si, Yang Liu, Haofeng Qiu, Chongyun Tan et autres

Abstract Cationic antimicrobial polymers exhibit potent antibacterial activity but frequently suffer from nonspecific interactions, systemic toxicity, and unfavorable in vivo disposition. Glycosylation offers a potential strategy to improve their biological compatibility; however, its effects on the in vivo pharmacokinetics and organ distribution …

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Varying Carbene Persistence in Membrane as a Mechanism for Modulating Antibacterial Carbon Acid Oligomer Killing Efficacy

Quang Huy Nhat Vu, Chongyun Tan, Mallikharjuna Rao Lambu, Zheng Wang et autres

ABSTRACT We previously proposed that cationic oligoimidazolium (OIM) carbon acids kill bacteria via an N‐heterocyclic carbene (NHC)‐assisted translocation process to reach intracellular targets. Herein, we found that the linkers joining the imidazolium rings in OIM chains profoundly affect the oligomers’ cytosolic uptakes, …

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Varying Carbene Persistence in Membrane as a Mechanism for Modulating Antibacterial Carbon Acid Oligomer Killing Efficacy

Quang Huy Nhat Vu, Chongyun Tan, Mallikharjuna Rao Lambu, Zheng Wang et autres

We previously proposed that cationic oligoimidazolium (OIM) carbon acids kill bacteria via an N-heterocyclic carbene (NHC)-assisted translocation process to reach intracellular targets. Herein, we found that the linkers joining the imidazolium rings in OIM chains profoundly affect the oligomers' cytosolic uptakes, which …

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Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria

Xiaofei Xu, Chiranjeevi Korupalli, Divyanshu Mahajan, Chongyun Tan et autres

Drug resistance in bacteria is a major problem that calls for new classes of antimicrobial drugs. We report a biodegradable poly(imidazolium ester) (PIE), P8, with excellent broad-spectrum antibacterial activity, high therapeutic selectivity, and an unexploited mechanism of action. P8, a short oligomer, …

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Author Correction: Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing

Dicky Pranantyo, Chun Kiat Yeo, Yang Wu, Chen Fan et autres

In the original version of the article, an error in Fig. 4c resulted in a duplicated image being included. This did not affect the conclusions. Separately from this, some discussion of the maturation of keratinocytes used imprecise language, and although this did …

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Lipase-Responsive Nitric Oxide Releasing Degradable Nanoparticles Targeting Bacterial Biofilm

Yuan Qu, Mary Bee Eng Chan‐Park

Nitric oxide (NO) has shown promising potential for biofilm dispersal, but small NONOate (diazeniumdiolate) molecules have rapid diffusion, short half-life, and uncontrolled release, which limit their therapeutic applications. Grafting NO donors onto a polymer backbone reduces uncontrolled release and toxicity. However, previous …

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Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers

Chong Hui Koh, Mallikharjuna Rao Lambu, Chongyun Tan, Guangmin Wei et autres

Cationic polymers have emerged as promising next-generation antimicrobial agents, albeit with inherent limitations such as low potency and limited biocompatibility. Classical cationic polymers kill bacteria via physical membrane disruption. We propose a non-classical mechanism of crossing the bacterial plasma membrane barrier, a …

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Chemical Innovations of Antimicrobial Polymers for Combating Antimicrobial Resistance

Zhangyong Si, Mary Bee Eng Chan‐Park

The global rise of antimicrobial resistance (AMR) has rendered many traditional antibiotics ineffective, leading to an urgent need for alternative therapeutic strategies. Antimicrobial polymers, with their ability to rapidly kill bacteria by disrupting or crossing membranes and/or targeting multiple microbial functions without …

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A Near-Infrared Fluorescent Nanosensor for Direct and Real-Time Measurement of Indole-3-Acetic Acid in Plants

Duc Thinh Khong, Kien Van Vu, Benny Jian Rong Sng, Ian Kin Yuen Choi et autres

Auxin, particularly indole-3-acetic acid (IAA), is a phytohormone critical for plant growth, development, and response to environmental stresses like shade avoidance syndrome and thermomorphogenesis. Despite its importance, there is no existing method that allows for convenient and direct detection of IAA in …

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A cationic main-chain poly(carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice

Zhangyong Si, Yan Sun, Ying Jie Ooi, Ming Li et autres

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Enzyme‐Responsive Polyion Complex Nanoparticles of Cationic Antimicrobials for Activatable Antibacterial Therapy

Bo Zhang, Derong Lu, Dennis Bao Rong Wang, Zhi Yuan Kok et autres

Abstract A self‐assembled “caging” strategy is presented for the safe delivery of potent cationic antimicrobials that suffer from non‐specific toxicity for the effective treatment of in vivo systemic bacterial infection. The key development here is a new block copolymer consisting of a …

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An optimized cyclophosphamide-treated mouse model of Mycobacterium abscessus pulmonary infection

Yan Sun, Kaixi Zhang, May Delos Santos, Carmen J. E. Pee et autres

ABSTRACT Mycobacterium abscessus pulmonary infections are increasingly problematic, especially for immunocompromised individuals and those with underlying lung conditions. Currently, there is no reliable standardized treatment, underscoring the need for improved preclinical drug testing. We present a simplified immunosuppressed mouse model using only …

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