2026
article
OpenAlex
Quang Huy Nhat Vu, Chongyun Tan, Mallikharjuna Rao Lambu, Zheng Wang et autres
ABSTRACT We previously proposed that cationic oligoimidazolium (OIM) carbon acids kill bacteria via an N‐heterocyclic carbene (NHC)‐assisted translocation process to reach intracellular targets. Herein, we found that the linkers joining the imidazolium rings in OIM chains profoundly affect the oligomers’ cytosolic uptakes, …
sg
(code pays fourni par la source)
2026
article
OpenAlex
Quang Huy Nhat Vu, Chongyun Tan, Mallikharjuna Rao Lambu, Zheng Wang et autres
We previously proposed that cationic oligoimidazolium (OIM) carbon acids kill bacteria via an N-heterocyclic carbene (NHC)-assisted translocation process to reach intracellular targets. Herein, we found that the linkers joining the imidazolium rings in OIM chains profoundly affect the oligomers' cytosolic uptakes, which …
sg
(code pays fourni par la source)
2026
article
OpenAlex
Bo Zhang, Mallikharjuna Rao Lambu, Derong Lu, Tingyu Wang et autres
Antimicrobial peptides (AMPs) are promising alternative agents to combat the escalating antimicrobial resistance (AMR) crisis, yet their application is often limited by inherent toxicity and suboptimal performance due to poor selectivity against pathogenic bacteria. In this study, we developed a series of …
sg, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiaofei Xu, Chiranjeevi Korupalli, Divyanshu Mahajan, Chongyun Tan et autres
Drug resistance in bacteria is a major problem that calls for new classes of antimicrobial drugs. We report a biodegradable poly(imidazolium ester) (PIE), P8, with excellent broad-spectrum antibacterial activity, high therapeutic selectivity, and an unexploited mechanism of action. P8, a short oligomer, …
sg, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Chong Hui Koh, Mallikharjuna Rao Lambu, Chongyun Tan, Guangmin Wei et autres
Cationic polymers have emerged as promising next-generation antimicrobial agents, albeit with inherent limitations such as low potency and limited biocompatibility. Classical cationic polymers kill bacteria via physical membrane disruption. We propose a non-classical mechanism of crossing the bacterial plasma membrane barrier, a …
sg, us, sk, cn, gb
(code pays fourni par la source)