Zhi Yuan Kok

Small-molecule fluorescent probes for the aminergic GPCRs – What new tool compounds do we have post-2014 and what can they do?

Christopher Zi Qian Choo, Joey Yun Xuan Ching, Myra Mazhar Ud Deen, Zhi Yuan Kok

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Small-molecule fluorescent probes for the aminergic GPCRs -- What new tool compounds do we have post-2014 and what can they do?

Christopher Zi Qian Choo, M. Jamal Deen, Zhi Yuan Kok

Aminergic GPCRs are heavily involved in the physiological functions of the human body and are prominent drug targets for numerous diseases. Despite the extensive work that has been done over the years surrounding the aminergic GPCRs, knowledge gaps persist as not all …

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Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers

Chong Hui Koh, Mallikharjuna Rao Lambu, Chongyun Tan, Guangmin Wei et autres

Cationic polymers have emerged as promising next-generation antimicrobial agents, albeit with inherent limitations such as low potency and limited biocompatibility. Classical cationic polymers kill bacteria via physical membrane disruption. We propose a non-classical mechanism of crossing the bacterial plasma membrane barrier, a …

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Enzyme‐Responsive Polyion Complex Nanoparticles of Cationic Antimicrobials for Activatable Antibacterial Therapy

Bo Zhang, Derong Lu, Dennis Bao Rong Wang, Zhi Yuan Kok et autres

Abstract A self‐assembled “caging” strategy is presented for the safe delivery of potent cationic antimicrobials that suffer from non‐specific toxicity for the effective treatment of in vivo systemic bacterial infection. The key development here is a new block copolymer consisting of a …

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Membrane Potential-Dependent Uptake of Cationic Oligoimidazolium Mediates Bacterial DNA Damage and Death

Melvin Yong, Zhi Yuan Kok, Chong Hui Koh, Wenbin Zhong et autres

The treatment of bacterial infections is becoming increasingly challenging with the emergence of antimicrobial resistance. Thus, the development of antimicrobials with novel mechanisms of action is much needed. Previously, we designed several cationic main-chain imidazolium compounds and identified the polyimidazolium PIM1 as …

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Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor

Zhi Yuan Kok, Leigh A. Stoddart, Sarah J. Mistry, Tamara A. M. Mocking et autres

R predicts that the optimized peptide linker makes interactions with key residues in the receptor.

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