Santiago Martínez

New insights for an old drug: difluoromethylornithine boosts the trypanocidal action of benznidazole on Trypanosoma cruzi in vitro and in vivo

Santiago Martínez, M. Cristina Vanrell, Xiaomo Li, Carolina Carrillo et autres

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi , is currently a global health problem. Its multiple forms of transmission, which favor the spread of the infection, and the limited treatment options—still restricted to only two drugs—highlight the urgent need for …

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357 A NOVEL AZETIDINE-BASED STAT3 INHIBITOR INDUCES ANTI-TUMOR RESPONSES IN EXPERIMENTAL MODELS OF PANCREATIC CANCER

Santiago Martínez, Richard T. Waldron, Lihong Huo, Peibin Yue et autres

Utilización de álamos y sauces para la producción de biomasa para energía

Virginia Luquez, Mauro Bartolozzi, Santiago Martínez

En esta revisión, se describen las principales características del uso de Salicáceas (álamos y sauces) en plantaciones de rotación corta para producir biomasa para energía. Se analizan distintos tipos de plantaciones para producir biomasa y la sustentabilidad de las mismas. Se resumen …

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Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells

María Cristina Vanrell, Santiago Martínez, Lucila Ibel Muñoz, Betiana Nebaí Salassa et autres

Chagas disease, caused by the parasite Trypanosoma cruzi, is an infectious illness endemic to Latin America and still lacks an effective treatment for the chronic stage. In a previous study in our laboratory, we established the protective role of host autophagy in …

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Biological Features of Tcm: A New Trypanosoma Cruzi Isolate from Argentina (Dtu V) Displaying Slow Growth, Cardiac Tropism, and Susceptibility to Benznidazole

Patricia Silvia Romano, Santiago Martínez, Gonzalo Nardella, Matías Exequiel Rodríguez et autres

Biological features of TcM: A new Trypanosoma cruzi isolate from Argentina classified into TcV lineage

Santiago Martínez, Gonzalo Nardella, Matías Exequiel Rodríguez, Cynthia Vanesa Rivero et autres

Trypanosoma cruzi, the etiologic agent of Chagas disease (CD) presents a wide genetic and phenotypic diversity that is classified into seven lineages or discrete typing units (DTU: TcI to TcVI and Tcbat). Although isolates and strains that belong to a particular group …

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Repurposing Carvedilol as a Novel Inhibitor of the Trypanosoma cruzi Autophagy Flux That Affects Parasite Replication and Survival

Cynthia Vanesa Rivero, Santiago Martínez, Paul Novick, Juan Agustín Cueto et autres

T. cruzi, the causal agent of Chagas disease, is a parasite able to infect different types of host cells and to persist chronically in the tissues of human and animal hosts. These qualities and the lack of an effective treatment for the …

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Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection

Xiaomo Li, Sijia Yi, Débora B. Scariot, Santiago Martínez et autres

Chagas disease is caused by infection with the protozoan parasite Trypanosoma cruzi (T. cruzi), an intracellular pathogen that causes significant morbidity and death among millions in the Americas from Canada to Argentina. Current therapy involves oral administration of the nitroimidazole benznidazole (BNZ), …

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Ursolic acid promotes clearance of Trypanosoma cruzi amastigotes in the host cell

Patricia Silvia Romano, María Cristina Vanrell, Santiago Martínez, Lucila Ibel Muñoz et autres

Trypanosoma cruzi is the etiological agent of Chagas disease, which is endemic in Latin America. Ursolic acid (UA) is a natural pentacyclic triterpene which has been shown to reduce the peak of parasitemia in T. cruzi infected mice. Due to UA was …

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Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy

Santiago Martínez, Patricia Silvia Romano, David M. Engman

Chagas disease is a disease of the heart (cardiomyopathy) or gastrointestinal tract (megaesophagus or megacolon) that develops in approximately one-third of people infected with the protozoan parasite Trypanosoma cruzi. T. cruzi is a zoonosis transmitted among animals and people through contact with …

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Induction of autophagy increases the proteolytic activity of reservosomes duringTrypanosoma cruzimetacyclogenesis

Antonella Denise Losinno, Santiago Martínez, Carlos A. Labriola, Carolina Carrillo et autres

Cruzipain, the major cysteine protease of the pathogenic protozoa Trypanosoma cruzi, is an important virulence factor that plays a key role in the parasite nutrition, differentiation and host cell infection. Cruzipain is synthesized as a zymogen, matured, and delivered to reservosomes. These …

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Induction of autophagy increases the proteolytic activity of reservosomes during Trypanosoma cruzi metacyclogenesis

Antonella Denise Losinno, Santiago Martínez, Carlos A. Labriola, Carolina Carrillo et autres

Cruzipain, the major cysteine protease of the pathogenic protozoa Trypanosoma cruzi, is an important virulence factor that plays a key role in the parasite nutrition, differentiation and host cell infection. Cruzipain is synthesized as a zymogen, matured, and delivered to reservosomes. These …