Yixiao Mei

STIM1 functionally couples to transient receptor potential ankyrin 1 contributing to nociception

Yixiao Mei, Hareram Birla, Bo Hyun Lee, Zhixiao Li et autres

ABSTRACT: STIM1 is a calcium sensor that can sense calcium level changes in the endoplasmic reticulum (ER) and respond to extracellular stimuli. We have reported that STIM1 is expressed in nociceptors. However, its functional significance remains unclear. Here, we show that STIM1 …

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Amphiregulin contributes to neuropathic pain by enhancing glycolysis that stimulates histone lactylation in sensory neurons

Yu-Tao Deng, Longfei Ma, Yixiao Mei, Ji-Shuai Wang et autres

The genesis of neuropathic pain after peripheral nerve injury is associated with changes in gene expression and cell metabolism in sensory neurons and the release of inflammatory cytokines. Here, we connected glycolytic metabolism induced by the epidermal growth factor receptor (EGFR) ligand …

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From sensation to regulation: the diverse functions of peripheral sensory nervous system

Yixiao Mei, Binglin Zhou, Da Zhong, Yu-Tao Deng et autres

The peripheral sensory nervous system (PNS) has been widely recognized for its role in the collection, processing, and transmission of sensory information, including thermal, mechanical, chemical, and proprioceptive stimuli. In recent years, there has been a growing scholarly interest in the PNS …

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An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord

Fulu Dong, Lina Yu, Pei-Da Feng, Jinxuan Ren et autres

Peripheral nerve injury (PNI)-induced neuropathic pain (NP) is a severe disease with high prevalence in clinics. Gene reprogramming and tissue remodeling in the dorsal root ganglia (DRG) and spinal cord (SC) drive the development and maintenance of neuropathic pain (NP). However, our …

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PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization

Dongyu Wei, Hareram Birla, Yannong Dou, Yixiao Mei et autres

Peripheral sensitization is one of the primary mechanisms underlying the pathogenesis of chronic pain. However, candidate molecules involved in peripheral sensitization remain incompletely understood. We have shown that store-operated calcium channels (SOCs) are expressed in the dorsal root ganglion (DRG) neurons. Whether …

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PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing To Peripheral Sensitization

Dongyu Wei, Yixiao Mei, Yannong Dou, Xiaodong Huo et autres

Overall buckling behaviour of superior high-performance steel columns under fire

Yixiao Mei, Huiyong Ban, Guohao Zhou, Yongjiu Shi et autres

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Orai1 is a crucial downstream partner of group I metabotropic glutamate receptor signaling in dorsal horn neurons

Jingsheng Xia, Yannong Dou, Yixiao Mei, Frances M. Muñoz et autres

ABSTRACT: Group I metabotropic glutamate receptors (group I mGluRs) have been implicated in several central nervous system diseases including chronic pain. It is known that activation of group I mGluRs results in the production of inositol triphosphate (IP3) and diacylglycerol that leads …

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Reactive oxygen species play a role in P2X7 receptor-mediated IL-6 production in spinal astrocytes

Frances M. Muñoz, Priya A. Patel, Xinghua Gao, Yixiao Mei et autres

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Calcium release-activated calcium channels and pain

Yixiao Mei, James E. Barrett, Huijuan Hu

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Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons

Dongyu Wei, Yixiao Mei, Jingsheng Xia, Huijuan Hu

Store-operated calcium channels (SOCs) are highly calcium-selective channels that mediate calcium entry in various cell types. We have previously reported that intraplantar injection of YM-58483 (a SOC inhibitor) attenuates chronic pain. A previous study has reported that the function of SOCs in …

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Identification and Characterization of a Bacterial Homolog of Chloride Intracellular Channel (CLIC) Protein

Shubha Gururaja Rao, Devasena Ponnalagu, Sowmya Sukur, Harkewal Singh et autres

Chloride intracellular channels (CLIC) are non-classical ion channels lacking a signal sequence for membrane targeting. In eukaryotes, they are implicated in cell volume regulation, acidification, and cell cycle. CLICs resemble the omega class of Glutathione S-transferases (GST), yet differ from them in …

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