Yannong Dou

A spinoreticular pathway mediates nocifensive responses to noxious mechanical stimuli

Yuan Liu, Qing Li, Jun-Kai Lin, Yifei Han et autres

Spinal projection neurons (SPNs) relay somatosensory information to the brain, yet how molecularly defined SPN subsets transmit noxious mechanical signals to drive nocifensive behaviors remains unclear. Here, we identify Sncg -expressing SPNs ( Sncg + SPNs) that convey noxious mechanical signals through …

cn (code pays fourni par la source)

Single-Neuron Connectome of the Central Amygdala in the Mouse Brain

Lin-Han Wang, Wei Song, Xu Chen, Qing Li et autres

The central amygdala (CeA) orchestrates defensive behaviors, pain processing, and stress responses, yet how its molecularly defined neuronal subtypes are embedded in brain-wide circuits remains unclear. Here, we reconstructed the brain-wide input and output architecture of three neuronal subtypes, CeA Sst , …

cn (code pays fourni par la source)

Evolutionary convergence and divergence of hippocampal cytoarchitecture between rodents and primates revealed by single-cell spatial transcriptomics

Tianyi Fei, Yu Dong, Xiaojuan Gou, Jiahao Zhang et autres

ABSTRACT The hippocampus comprises subregions of distinct cell types critical for memory and cognition, but their gene expression profiles and spatial distribution patterns remain to be clarified. Using single-cell spatial transcriptomic analysis and single-nucleus RNA sequencing, we obtained transcriptome-based atlases for the …

cn, Botswana, se (code pays fourni par la source)

Transcriptomic and spatial organization of mouse spinal cord projection neurons

Jun-Kai Lin, Yuan Liu, Juan Deng, Lin-Han Wang et autres

The spinal cord projection neurons (SPNs) convey diverse modalities of somatosensory information from the spinal cord to the brain, but their molecular and cellular heterogeneity and organization remain largely unknown. Using retrograde labeling and single-cell transcriptomic analysis, we identified 15 SPN subtypes …

cn (code pays fourni par la source)

Integrative analysis of single-neuron projectomes links connectome, transcriptome, and function in the mouse cortex

Le Gao, Haifang Wang, Lin Chen, Zhaoqin Chen et autres

cn (code pays fourni par la source)

Single-cell spatial transcriptome atlas and whole-brain connectivity of the macaque claustrum

Ying Lei, Yuxuan Liu, Mingli Wang, Nini Yuan et autres

Claustrum orchestrates brain functions via its connections with numerous brain regions, but its molecular and cellular organization remains unresolved. Single-nucleus RNA sequencing of 227,750 macaque claustral cells identified 48 transcriptome-defined cell types, with most glutamatergic neurons similar to deep-layer insular neurons. Comparison …

cn, fr, Botswana (code pays fourni par la source)

Single-cell spatial transcriptomic atlas of the whole mouse brain

Lei Han, Zhen Liu, Zehua Jing, Yuxuan Liu et autres

cn, Botswana (code pays fourni par la source)

Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

Yannong Dou, Yuan Liu, Wen-Qun Ding, Qing Li et autres

ABSTRACT Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors (MORs) in GABAergic neurons of the central amygdala nucleus …

cn (code pays fourni par la source)

Corrigendum to “Norisoboldine ameliorates collagen-induced arthritis through regulating the balance between Th17 and regulatory T cells in gut-associated lymphoid tissues” [Toxicology and Applied Pharmacology, 282/1 (2015) 90–99].

Bei Tong, Yannong Dou, Ting Wang, Juntao Yu et autres

cn (code pays fourni par la source)

Spinal Nmur2-positive Neurons Play a Crucial Role in Mechanical Itch

Junfeng Xu, Lian Liu, Yuan Liu, Ke-Xing Lu et autres

cn (code pays fourni par la source)

Spatially resolved molecular and cellular atlas of the mouse brain

Lei Han, Zhen Liu, Zehua Jing, Yuxuan Liu et autres

Abstract A comprehensive atlas of genes, cell types, and their spatial distribution across a whole mammalian brain is fundamental for understanding function of the brain. Here, using snRNA-seq and Stereo-seq techniques, we generated a mouse brain atlas with spatial information for 308 …

cn (code pays fourni par la source)

PGE2 Potentiates Orai1-Mediated Calcium Entry Contributing to Peripheral Sensitization

Dongyu Wei, Hareram Birla, Yannong Dou, Yixiao Mei et autres

Peripheral sensitization is one of the primary mechanisms underlying the pathogenesis of chronic pain. However, candidate molecules involved in peripheral sensitization remain incompletely understood. We have shown that store-operated calcium channels (SOCs) are expressed in the dorsal root ganglion (DRG) neurons. Whether …

us (code pays fourni par la source)