Bo Hyun Lee

STIM1 functionally couples to transient receptor potential ankyrin 1 contributing to nociception

Yixiao Mei, Hareram Birla, Bo Hyun Lee, Zhixiao Li et autres

ABSTRACT: STIM1 is a calcium sensor that can sense calcium level changes in the endoplasmic reticulum (ER) and respond to extracellular stimuli. We have reported that STIM1 is expressed in nociceptors. However, its functional significance remains unclear. Here, we show that STIM1 …

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Molecular details of ruthenium red pore block in TRPV channels

Ruth A. Pumroy, Jose Juan De Jesus-Perez, Anna D. Protopopova, Julia A Rocereta et autres

Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal pore blocker for a wide array of cation channels. Here we use …

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Interaction of Thiol Antioxidants with α,β-Unsaturated Ketone Moiety: Its Implication for Stability and Bioactivity of Curcuminoids

Bo Hyun Lee, Eiseul Song, Jungil Hong

Many biological functions of curcumin have been reported. As certain bioactivities of curcumin are eliminated by antioxidants, reactive oxygen species generated by curcumin have been suggested as a relevant mechanism. In the present study, the effects of different types of antioxidants on …

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Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A

Bo Hyun Lee, José J De Jesús Pérez, Vera Y. Moiseenkova‐Bell, Tibor Rohács

Abstract Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays important cellular regulatory roles, including activation and inhibition of ion channels. The structural basis of ion channel regulation by LC-CoA is not known. Transient receptor potential vanilloid 5 and 6 …

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Interaction of Thiol Antioxidants with a,β-Unsaturated Ketone Moiety of Curcumin; Its Implication for Stability and Bioactivity of Curcuminoids

Bo Hyun Lee, Eiseul Song, Jungil Hong

Many biological functions of curcumin have been reported. As certain bioactivities of curcumin are eliminated by antioxidants, reactive oxygen species generated by curcumin have been suggested as a relevant mechanism. In the present study, effects of different types of antioxidants on stability …

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Monitoring trafficking and expression of hemagglutinin-tagged transient receptor potential melastatin 4 channel in mammalian cells

Eun Mi Hwang, Bo Hyun Lee, Eun Hye Byun, Soomin Lee et autres

-activated monovalent cation channel called transient receptor potential melastatin 4 (TRPM4) that is expressed in various tissues. Dysregulation or abnormal expression of TRPM4 has been linked to a range of diseases. We introduced the hemagglutinin (HA) tag into the extracellular S6 loop …

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Roles of anti- and pro-oxidant potential of cinnamic acid and phenylpropanoid derivatives in modulating growth of cultured cells

Bo Hyun Lee, Hyeon‐Son Choi, Jungil Hong

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Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland

Bo Hyun Lee, Bertil Hille, Duk‐Su Koh

Significance The pineal gland secretes melatonin at night mainly driven by adrenergic sympathetic inputs. Many other neurotransmitters are found in the pineal gland, suggesting potential fine modulation of melatonin release. Serotonin as a precursor of melatonin synthesis is known to be significantly …

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Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites

Aysenur Torun Yazici, Eleonora Gianti, Marina A. Kasimova, Bo Hyun Lee et autres

Regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial. In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinositides were proposed to act …

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An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel

Fan Yang, Lizhen Xu, Bo Hyun Lee, Xian Xiao et autres

While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative …

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1090-P: MSDC-0602k, a New Oral Insulin Sensitizer in Insulin Resistant NASH Patients with and without Type 2 Diabetes (T2D)

Jerry R. Colca, Bo Hyun Lee, Julie Iwashita, Howard C. Dittrich et autres

Use of the first-generation insulin sensitizer pioglitazone is limited by PPARγ-driven side effects. MSDC-0602K was designed to maintain pioglitazone’s effects on the mitochondrial pyruvate carrier (MPC), but with minimal direct PPARγ binding. A 12-month Phase 2b dose-ranging study in NASH (Harrison et …

An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel

Lizhen Xu, Bo Hyun Lee, Xian Xiao, Vladimir Yarov‐Yarovoy et autres

Abstract While the capsaicin receptor TRPV1 channel is a polymodal nociceptor for heat, capsaicin, and proton, the channel’s responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative voltages and amplifying its …

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