Huijuan Hu

Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration

Shasha Li, Hui Liu, Shaohui Pan, Shun Zhang et autres

Restoring retinal pigment epithelium (RPE) cells is crucial for treating retinal degenerative (RD) diseases, with chemical reprogramming offering a transformative, scalable solution. However, identifying key chemical compounds for generating functional RPE cells from somatic cells remains challenging. Here, we present a two-step …

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Proneurotrophin-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons

Dilip Kumar Sharma, Xiaozhou Feng, Bing Wang, Huijie Shang et autres

Cancer patients undergoing treatment with antineoplastic drugs often experience chemotherapy-induced neuropathic pain (CINP), and therapeutic options for managing CINP are limited. Here, we show that systemic paclitaxel administration upregulates the expression of neurotrophin-3 (Nt3) mRNA and its encoded proneurotrophin-3 (proNT3) protein in …

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Withdrawal Note: NT-3 contributes to chemotherapy-induced neuropathic pain through TrkC-mediated CCL2 elevation in DRG neurons

Dilip Kumar Sharma, Xiaozhou Feng, Bing Wang, Bushra Yasin et autres

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Chemical Origin and Transport Limits of Current Multiplication in BiVO4 Photoanodes

Jie Ouyang, Huijuan Hu, Na Deng, Yujie Ren et autres

Current multiplication, where more than one electron transfer per photon absorbed, has the potential to transform photoelectrochemical solar fuel generation. Yet it remains rarely realized, largely because the underlying chemical pathways enabling this process are poorly understood and key bottlenecks are still …

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STIM1 functionally couples to transient receptor potential ankyrin 1 contributing to nociception

Yixiao Mei, Hareram Birla, Bo Hyun Lee, Zhixiao Li et autres

ABSTRACT: STIM1 is a calcium sensor that can sense calcium level changes in the endoplasmic reticulum (ER) and respond to extracellular stimuli. We have reported that STIM1 is expressed in nociceptors. However, its functional significance remains unclear. Here, we show that STIM1 …

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Leveraging deep learning to discover interpretable cellular spatial biomarkers for prognostic predictions based on hepatocellular carcinoma histology

Huijuan Hu, Tianhua Tan, Yerong Liu, Wei Yan Liang et autres

The spatial structure of various cell types in the tumour microenvironment (TME) can provide valuable insights into disease progression. However, identifying the spatial organization of diverse cell types that significantly correlates with patient prognosis remains challenging. In this study, enabled by deep …

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Lysophosphatidic acid receptor 5 in insular cortex as a potential analgesic target in neuropathic pain

Bing Wang, Xiaozhou Feng, Kristen L. Woodhouse, Dilip Kumar Sharma et autres

Neuropathic pain remains a significant clinical challenge and existing treatments have limited efficacy and often over rely on opioids. Pharmacological inhibition and genetic knockout of lysophosphatidic acid receptor 5 (LPA5) lead to an analgesic effect on nerve injury-induced nociceptive hypersensitivity in rodents. …

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A0069 – The efficacy and safety of disitamab vedotin (RC48-ADC) combined with immune checkpoint inhibitors in patients with metastatic upper tract urothelial carcinoma: A multicenter real-world study

Chau Yee Ng, Tiantian Jing, Guipeng Ding, Shuguang Zhang et autres

Small non-coding RNA profiling in patients with non-muscle invasive bladder cancer

Jiajia Cai, Zeqin Yan, Yadi Zhong, Yuqing Li et autres

The intricate regulatory roles of small non-coding RNAs (sncRNAs), including PIWI-interacting RNAs (piRNAs) and microRNAs (miRNAs), have been increasingly recognized in the modulation of cellular functions and are associated with the pathogenesis of various diseases, notably cancer. However, the specific dysregulation patterns …

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Generation of a homozygous CPAMD8 knockout human embryonic stem cell line (WAe009-A-2R) by CRISPR/Cas9 system

Yuhe Renee Yang, Shun Zhang, Xiaoyu Liu, Huijuan Hu et autres

CPAMD8, a constituent of the A2M/C3 (α-2-macroglobulin/complement 3) protein family, is strikingly expressed in the human fetal lens and distal neural retina. Mutations in CPAMD8 have been linked to anterior segment dysgenesis and primary congenital glaucoma. We utilized CRISPR/Cas9 technology to establish …

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Polyclonal-to-monoclonal transition in colorectal precancerous evolution

Zhaolian Lu, Shanlan Mo, Duo Xie, Xiangwei Zhai et autres

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RNA-binding protein SYNCRIP contributes to neuropathic pain through stabilising CCR2 expression in primary sensory neurones

Yang Zhang, Bing Wang, Xiaozhou Feng, Huixing Wang et autres

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