Linchuan Li

Targeting drug-tolerant persister cells to overcome resistance in HER2-positive gastric cancer

Qian Xu, Linchuan Li, Siyi Song, Huanxin Ding et autres

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Exploring the regulatory mechanisms of paraptosis-related prognostic genes in gastric cancer using single-cell sequencing and transcriptome analysis

Zhengliang Liu, Ying Gao, Wenjie Zhang, Linchuan Li et autres

Previous studies have suggested a potential role for paraptosis-related genes (PRGs) in cancer pathogenesis, yet their prognostic significance and therapeutic efficacy in gastric cancer (GC) remain largely unexplored. This study aims to investigate the function of PRGs in GC and offer valuable …

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Visceral fat area as a prognostic biomarker in gastric cancer: a systematic review and meta-analysis of survival outcomes

Lei Liu, Shufu Hou, Bing Yan, Ruiqi Hao et autres

Background: Visceral fat area (VFA) has been suggested as an alternative to body mass index (BMI) for evaluating the effects of obesity and fat distribution. Although VFA has shown potential as a predictor of perioperative complications and surgical duration, its prognostic value …

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Wernicke’s encephalopathy following radical gastrectomy and prolonged parenteral nutrition: a case report of pyloric obstruction and undisclosed psychiatric comorbidity

Hu Ma, Zheng Zhao, Wenjie Zhang, Shuaichen Jin et autres

Wernicke's encephalopathy (WE), a neuropsychiatric emergency caused by thiamine deficiency, is increasingly recognized in nonalcoholic populations. We present a 64-year-old male with pyloric obstruction from gastric cancer (stage IIIA) who developed WE 20 days after gastrectomy. Prolonged thiamine-free total parenteral nutrition (TPN), …

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Association between triglyceride-glucose related indices and at-risk NASH in U.S. adults with NAFLD: results from NHANES 2017-2020

Hu Ma, Wenjie Zhang, Zheng Zhao, Shuaichen Jin et autres

Introduction: Nonalcoholic fatty liver disease (NAFLD), intricately linked to insulin resistance (IR), obesity, and metabolic syndrome (MetS), affects nearly one-third of the global population. The triglyceride-glucose (TyG) index and its derivative metrics, which integrate anthropometric measures, have emerged as cost-effective tools for …

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RNF128 promotes gastric cancer progression by inhibiting autophagy-dependent ferroptosis through Beclin1 ubiquitination

Zhenguo Zhu, Qishuai Chen, Siyi Song, Shi Peng et autres

As an important protein post-translational modification process, ubiquitination plays an indispensable role in the regulation of gastric cancer (GC) occurrence and development. And recent studies have demonstrated that this modification is closely related to regulated cell death. This suggests that our therapeutic …

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Application of a novel anvil holder clamp in laparoscopic gastrectomy

Yong Qi, Linchuan Li, Bo Li, Sanyuan Hu et autres

Background: The reverse puncture method is a common reconstruction technique used in radical gastrectomy for gastric cancer. However, its widespread use is limited due to unstable clamping and unstable force directions, which complicate the anastomosis process. Therefore, we aimed to develop an …

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The prognostic value of circulating tumor DNA in malignant melanoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis

Lei Liu, Shufu Hou, Aiping Zhu, Bing Yan et autres

Background: Circulating tumor DNA (ctDNA) is an emerging biomarker in malignant melanoma(MM), and high levels of ctDNA may reflect a higher tumor load. However, its prognostic value for MM receiving immune checkpoint inhibitors(ICI) remains controversial. This meta-analysis aimed to elucidate the prognostic …

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Hepatoid adenocarcinoma of the stomach with ideal response to neoadjuvant chemo-immunotherapy: a case report

Linchuan Li, Dexu Zhang, Jiankang Zhu, Guangyong Zhang

Hepatoid adenocarcinoma of the stomach (HAS) is a rare subtype of gastric cancer characterized by histological features resembling hepatocellular carcinoma. Surgical intervention remains the preferred treatment modality for eligible patients. However, the efficacy of neoadjuvant therapy and alternative treatment regimens has been …

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Resistance to Target Combined Chemotherapy in HER2-Positive Advanced Gastric Cancer Mediated by a Temporary Tolerant State

Qian Xu, Mingguang Zhang, Linchuan Li, Siyi Song et autres

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The CRISPR/Cas system-mediated function of Hg2+ on urease activity for colorimetric detection of the tumor biomarker in clinical samples

Xin Jin, Jian‐Kang Zhu, Yun Zhang, Shuaichen Jin et autres

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Acute Laceration in the Transverse Mesocolon After a Colonoscopy: A Case Report

Yongbo Zhang, Linchuan Li, Changhong Liu, Mingwen Jiao et autres

Colonoscopy is a widely used examination for colonic diseases with low risk. Hemoperitoneum due to injury of transverse mesocolon is an extremely rare but potentially lethal complication. We present a case of an elderly woman who complained of continuous abdominal pain after …

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