Guangyong Zhang

Adipocyte GDI2 suppresses lipophagy to restrain adaptive thermogenesis and promotes diet-induced obesity

Fei Gao, Yu Zhang, Dong Liu, Yufan Song et autres

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pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy

Qian Xu, Xin Jin, Siyi Song, Hongyu Zhang et autres

Gastric cancer (GC) remains a major global health burden, with limited effective therapies and poor prognosis. Quercetin (Que), a natural flavonoid, exhibits anticancer activity but suffers from poor water solubility, limited oral bioavailability, and rapid metabolic clearance, which severely restrict its clinical …

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Clinicopathological features and prognosis of patients with colorectal Mucinous adenocarcinoma mixed with other pathological components: a nationwide retrospective study in China

Jianlin Yuan, Hao He, Ping Zhang, Xu Guan et autres

BACKGROUND: Mucinous adenocarcinoma (MAC) is typically admixed with other pathological components, including conventional adenocarcinoma, signet ring cell carcinoma, and/or neuroendocrine neoplasms. Specifically, signet ring cell differentiation (MASD) is defined as a signet ring cell component comprising less than 50% of the tumor, …

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Clinicopathological characteristics and prognosis of patients with mucious adenocarcinoma originating from the left colon, right colon, or rectum: A nationwide retrospective study in China

Bingxu Liu, Haoqing He, Xu Guan, Peng Zhang et autres

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Nanozymes induced Z-scheme Mn-BiVO4/Au/Bi2S3 heterostructure photoelectrochemical signal amplification for CA72-4 detection

Shi Peng, Zhiqiang Wu, Qian Xu, Huanxin Ding et autres

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Exploring the regulatory mechanisms of paraptosis-related prognostic genes in gastric cancer using single-cell sequencing and transcriptome analysis

Zhengliang Liu, Ying Gao, Wenjie Zhang, Linchuan Li et autres

Previous studies have suggested a potential role for paraptosis-related genes (PRGs) in cancer pathogenesis, yet their prognostic significance and therapeutic efficacy in gastric cancer (GC) remain largely unexplored. This study aims to investigate the function of PRGs in GC and offer valuable …

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Seasonal climate variability, human activity, and terrace mitigation of erosion in the Hani rice terraces, China, in 2020

Guangyong Zhang, Linxuan Miao, Sen Li

The Hani Terrace, a UNESCO agricultural heritage site in China, exemplifies soil and water conservation through its integrated forest-village-terrace-water system. However, seasonal climate variability and increased human activity are raising soil erosion risks, with seasonal patterns and drivers remaining insufficiently understood. This …

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Clinicopathological features and prognosis of patients with colorectal mucous adenocarcinoma mixed with other pathological components: A nationwide retrospective study in China

Haoqing He, Peng Zhang, Xu Guan, Minhao Yu et autres

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Inhibiting UPF1 methylation enhances tumor immunotherapy sensitivity by reducing nonsense-mediated mRNA decay

Shengyu Zhu, Dongjing Zhang, Changsheng Huang, Qian Xu et autres

Nonsense-mediated mRNA decay (NMD) is a conserved RNA surveillance mechanism. Inhibition of NMD leads to increased expression of tumor neoantigens encoded by genes with premature termination codons (PTCs), thereby enhancing tumor immunogenicity. In this study, we find that protein levels of up-frameshift …

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Wernicke’s encephalopathy following radical gastrectomy and prolonged parenteral nutrition: a case report of pyloric obstruction and undisclosed psychiatric comorbidity

Hu Ma, Zheng Zhao, Wenjie Zhang, Shuaichen Jin et autres

Wernicke's encephalopathy (WE), a neuropsychiatric emergency caused by thiamine deficiency, is increasingly recognized in nonalcoholic populations. We present a 64-year-old male with pyloric obstruction from gastric cancer (stage IIIA) who developed WE 20 days after gastrectomy. Prolonged thiamine-free total parenteral nutrition (TPN), …

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Association between triglyceride-glucose related indices and at-risk NASH in U.S. adults with NAFLD: results from NHANES 2017-2020

Hu Ma, Wenjie Zhang, Zheng Zhao, Shuaichen Jin et autres

Introduction: Nonalcoholic fatty liver disease (NAFLD), intricately linked to insulin resistance (IR), obesity, and metabolic syndrome (MetS), affects nearly one-third of the global population. The triglyceride-glucose (TyG) index and its derivative metrics, which integrate anthropometric measures, have emerged as cost-effective tools for …

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Optimizing lymph node evaluation in colorectal mucinous adenocarcinoma: a multicenter and population-based study

Yanlai Sun, Changqing Jing, Benjia Liang, Xu Guan et autres

BACKGROUND: While the currently recommended minimum number of examined lymph nodes (ELNs) for colorectal cancer is 12, the applicability of this standard to colorectal mucinous adenocarcinoma (MAC), a distinct tumor entity with high metastatic potential, remains controversial. This study aimed to establish …

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