Visceral fat area as a prognostic biomarker in gastric cancer: a systematic review and meta-analysis of survival outcomes
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Visceral fat area (VFA) has been suggested as an alternative to body mass index (BMI) for evaluating the effects of obesity and fat distribution. Although VFA has shown potential as a predictor of perioperative complications and surgical duration, its prognostic value in gastric cancer patients remains contentious. This meta-analysis aimed to elucidate the prognostic significance of VFA in this patient population. Methods: We searched the PubMed, Cochrane Library, CNKI, and EMBASE databases, including literature published up to July 31, 2024, to investigate the prognostic implications of VFA in postoperative and non-surgical gastric cancer patients. Outcome measures encompassed overall survival (OS), relapse-free survival (RFS), disease free survival (DFS). Results: A total of 6,054 eligible patients were selected from 12 studies. The results indicated a significant association between elevated VFA and improved OS and DFS/RFS (OS: HR 0.76, 95% CI 0.65-0.90, p = 0.001; DFS: HR 0.84, 95% CI 0.75-0.95, p = 0.004). Subgroup analyses were conducted to assess the robustness of these findings. Conclusions: This meta-analysis demonstrated that among patients with gastric cancer who underwent surgery or other treatments, elevated VFA was significantly associated with improved OS and DFS/RFS. Consequently, VFA may serve as a useful prognostic indicator for assessing the prognosis of gastric cancer patients following treatment. However, further prospective studies are necessary to validate these findings and confirm the reliability of VFA as a prognostic marker. Systematic review registration: https://inplasy.com/, identifier INPLASY202490078.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Visceral fat area as a prognostic biomarker in gastric cancer: a systematic review and meta-analysis of survival outcomes
- Date Crossref
- 08/09/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Shandong University pays non établi dans la noticeUniversité ou école supérieure
-
Shandong Provincial Hospital pays non établi dans la noticeÉtablissement de santé
-
Jinan Central Hospital pays non établi dans la noticeÉtablissement de santé
-
Shandong First Medical University Department of Gastrointestinal Surgery pays non établi dans la noticeUniversité ou école supérieure
-
Xintai People's Hospital pays non établi dans la noticeÉtablissement de santé
-
First Affiliated Hospital of Jinan University pays non établi dans la noticeÉtablissement de santé
-
Cheeloo College of Medicine Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
-
Xintai City People's Hospital Department of Gastrointestinal Surgery pays non établi dans la noticeÉtablissement de santé
Shandong University, Shandong Provincial Hospital et Jinan Central Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.