Accès ouvert
2025
article
OpenAlex
Maria L Tang, Ian S McFarlane, Christopher E. Overton, Erjola Hani et autres
OBJECTIVES: In 2023/24, England had its largest measles outbreak in a decade. Lags from symptom onset to test results made laboratory-confirmed case data inherently retrospective rather than real-time. Reporting lags varied by measles prevalence and testing purpose. Nowcasting models can predict future …
gb
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Accès ouvert
2025
preprint
OpenAlex
Maria L Tang, Ian S McFarlane, Christopher E. Overton, Erjola Hani et autres
Abstract Background From 2023 to 2024, England had the largest measles outbreak in over a decade. Lags from suspected cases’ symptom onset to the availability of test results mean laboratory-confirmed case data are inherently retrospective rather than real-time. Reporting lags vary by …
gb
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Accès ouvert
2023
article
OpenAlex
Bernadette Purcell, L Harvey Vince, O McManus, Paul Crook et autres
Abstract When two previously fit and well staff from a wildlife rescue centre were hospitalised in early September 2018 with severe pneumonia and meningitis symptoms, the Health Protection Team began an investigation. Possible diagnoses included influenza and legionella, although it was not …
gb
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Accès ouvert
2021
article
OpenAlex
Karthik Paranthaman, Piers AN Mook, Daniele Curtis, Edward-Wynne Evans et autres
An outbreak surveillance system for Salmonella integrating whole genome sequencing (WGS) and epidemiological data was developed in South East and London in 2016-17 to assess local WGS clusters for triage and investigation. Cases genetically linked within a 5 single-nucleotide polymorphism (SNP) single …
gb
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Accès ouvert
2019
article
OpenAlex
David J. Roberts, Grahame S Davis, Michelle Jayne Cole, Dixita Naik et autres
(CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target region. The prevalence of such variants among persons tested for …
gb
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Accès ouvert
2019
article
OpenAlex
Joanna May Kesten, Kaiseree Dias, Fiona M. Burns, Paul Crook et autres
BACKGROUND: Increasing rates of sexually transmitted infections (STIs) in men-who-have-sex-with-men (MSM) in England is a pressing public health concern. Interventions targeting MSM, including information provision that effectively promotes sexual health, are needed. To support such intervention development, it is necessary to understand …
gb, us
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2019
article
OpenAlex
Sangeeta Rana, Neil Macdonald, Patrick French, Jay Jarman et autres
Syphilis rates have been increasing in men who have sex with men (MSM) in London. To describe risk behaviour and refine public health interventions, we conducted prospective enhanced surveillance of new syphilis cases in MSM attending selected London sexual health clinics (SHCs) …
gb
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Accès ouvert
2019
article
OpenAlex
Marie Anne Chattaway, Nastassya L. Chandra, Anaïs Painset, Victoria Shah et autres
In 2017, an outbreak of gastroenteritis in England attributed to Salmonella Adjame was detected and investigated. With the introduction of whole genome sequencing (WGS) for microbial typing, methods for comparing international outbreak data require evaluation. A case was defined as a person …
gb, ie, dk
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Accès ouvert
2019
article
OpenAlex
Thomas Inns, Daniele Curtis, Paul Crook, Roberto Vivancos et autres
Current methods of control recruitment for case-control studies can be slow (a particular issue for outbreak investigations), resource-intensive and subject to a range of biases. Commercial market panels are a potential source of rapidly recruited controls. Our study evaluated food exposure data …
gb
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Accès ouvert
2018
article
OpenAlex
Hannah E. R. Evans, Hikaru Bolt, Ellen Heinsbroek, Bryony H. Lloyd et autres
outbreak from a common source following piercings between July and September 2016 in England. The multi-agency outbreak investigation included active case finding, microbiological testing of environmental samples and case specimens including Variable Number Tandem Repeat (VNTR) typing and a retrospective cohort study. …
gb, se
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Accès ouvert
2018
article
OpenAlex
Piers AN Mook, Daniel Gardiner, Neville Q. Verlander, Jacquelyn McCormick et autres
Since April 2014 all presumptive Salmonella isolates received by Public Health England (PHE) have been characterised using whole genome sequencing (WGS) and the genomic data generated used to identify clusters of infection. To inform the implementation and development of a national gastrointestinal …
gb
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Accès ouvert
2018
article
OpenAlex
Piers AN Mook, Daniel Gardiner, Sanch Kanagarajah, Marko Kerac et autres
Detecting gastrointestinal (GI) infection transmission among men who have sex with men (MSM) in England is complicated by a lack of routine sexual behavioural data. We investigated whether gender distributions might generate signals for increased transmission of GI pathogens among MSM. We …
gb
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