Bryony H. Lloyd

PKCβ Facilitates Leukemogenesis in Chronic Lymphocytic Leukaemia by Promoting Constitutive BCR-Mediated Signalling

Jodie Hay, Anuradha Tarafdar, Ailsa K. Holroyd, Hothri A. Moka et autres

B cell antigen receptor (BCR) signalling competence is critical for the pathogenesis of chronic lymphocytic leukaemia (CLL). Defining key proteins that facilitate these networks aid in the identification of targets for therapeutic exploitation. We previously demonstrated that reduced PKCα function in mouse …

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PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

Jodie Hay, Anuradha Tarafdar, Ailsa K. Holroyd, Hothri A. Moka et autres

Abstract B cell antigen receptor (BCR) signaling competence is critical for pathogenesis of chronic lymphocytic leukemia (CLL). Defining key proteins that facilitate these networks aid in the identification of targets for therapeutic exploitation. We previously demonstrated that reduced PKCα function in mouse …

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National outbreak of Pseudomonas aeruginosa associated with an aftercare solution following piercings, July to September 2016, England

Hannah E. R. Evans, Hikaru Bolt, Ellen Heinsbroek, Bryony H. Lloyd et autres

outbreak from a common source following piercings between July and September 2016 in England. The multi-agency outbreak investigation included active case finding, microbiological testing of environmental samples and case specimens including Variable Number Tandem Repeat (VNTR) typing and a retrospective cohort study. …

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Gene expression profiling in bladder cancer identifies potential therapeutic targets

Syed A. Hussain, Daniel H. Palmer, Wing‐Kin Syn, Joseph J. Sacco et autres

Despite advances in management, bladder cancer remains a major cause of cancer related complications. Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. …

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NOTCH1 mutations and extracapsular spread in oral squamous cell carcinoma lymph node metastasis

Priyanka Bhattacharya, Janet Mary Risk, Jagjit Dhanda, Richard E. Shaw et autres

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SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

Jagtar Dhanda, Asterios G. Triantafyllou, T. Lilogou, H. Kalarai et autres

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Effect of an anti‐gonadotropin‐releasing factor vaccine on sexual and aggressive behaviour in male pigs during the finishing period under A ustralian field conditions

Branko Karaconji, Bryony H. Lloyd, Nancy Campbell, David F. Meaney et autres

OBJECTIVE: The objective of this study was to evaluate the effectiveness of an anti-gonadotropin-releasing factor vaccine in controlling sexual and aggressive behaviour of male pigs in the late finishing period under Australian field conditions. METHODS: Male pigs from four consecutive batches over …

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SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

Jagtar Dhanda, Asterios G. Triantafyllou, Triantafillos Liloglou, Helen Kalirai et autres

BACKGROUND: Extracapsular spread (ECS) in cervical lymph nodes is the single-most prognostic clinical variable in oral squamous cell carcinoma (OSCC), but diagnosis is possible only after histopathological examination. A promising biomarker in the primary tumour, alpha smooth muscle actin (SMA) has been …

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CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia

Gillian G. Johnson, Ke Lin, Trevor F. Cox, Melanie Oates et autres

Fludarabine plus cyclophosphamide (FC) is the chemotherapy backbone of modern chronic lymphocytic leukemia (CLL) treatment. CYP2B6 is a polymorphic cytochrome P450 isoform that converts cyclophosphamide to its active form. This study investigated the possible impact of genetic variation in CYP2B6 on response …

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Authors’ reply.

Sarah L. Lake, Helen Kalirai, Andrew R Dodson, Sarah E. Coupland et autres

Genomic Amplification Is Not a Frequent Event in Uveal Melanomas

Manuel Jorge Rodrigues, David Gentien, Marc‐Henri Stern, Laurence Desjardins et autres

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Gene expression profiling in bladder cancer to identify potential therapeutic targets.

Syed A. Hussain, Daniel H. Palmer, Wing Kin Syn, Joseph J. Sacco et autres

4518 Background: Characterization of gene expression patterns in bladder cancer (BC) allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. Methods: Between 2004 and 2005, cystoscopic bladder biopsies were obtained from …

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