Alec J. Vincent

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

Dunxin Shen, Alec J. Vincent, Evan Udine, Yazead Buhidma et autres

Neurodegenerative diseases are characterized by the localized loss of neurons. Why cell death is triggered only in specific neuronal populations and whether it is the response to toxic insults or the initial cellular state that determines their vulnerability is unknown. To understand …

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Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1 transcription signature

Dunxin Shen, Alec J. Vincent, Evan Udine, Yazead Buhidma et autres

Summary A G4C2 repeat expansion in the gene C9orf72 (C9) is the most common genetic cause of sporadic and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). What determines why cell death is triggered only in specific neuronal populations, while others …

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A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models

Dongwei Xu, Alec J. Vincent, Andrés González‐Gutiérrez, Benjamin Aleyakpo et autres

Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation of insoluble protein deposits, it's …

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A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models

Dongwei Xu, Alec J. Vincent, Andrés González‐Gutiérrez, Benjamin Aleyakpo et autres

Abstract Brains are highly metabolically active organs, consuming 20% of an organisms’ energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation of insoluble protein deposits, …

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Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

Esther van Dam, Lucie A.G. van Leeuwen, Eliano dos Santos, Joel James et autres

High-sugar diets cause thirst, obesity, and metabolic dysregulation, leading to diseases including type 2 diabetes and shortened lifespan. However, the impact of obesity and water imbalance on health and survival is complex and difficult to disentangle. Here, we show that high sugar …

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Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

James H. Catterson, Mobina Khericha, Miranda C. Dyson, Alec J. Vincent et autres

Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one month of a 2-day fed:5-day …

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Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Hrvoje Augustin, Kieran McGourty, Marcus J. Allen, Sirisha Kudumala Madem et autres

Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox").Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a …

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Myostatin-like proteins regulate synaptic function and neuronal morphology

Hrvoje Augustin, Kieran McGourty, Joern R. Steinert, Helena M. Cochemé et autres

Growth factors of the TGF-β superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators of skeletal muscle mass. However, expression of both Myostatin and its cognate receptors in other tissues, including brain …

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Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

Teresa Niccoli, Melissa Cabecinha, Anna Tillmann, Fiona Kerr et autres

(Current Biology 26, 2291–2300; September 12, 2016) In this article, the neurons shown in Figure 1D were labeled with mtdTomato-3×HA, not GFP as originally stated in the Figure 1D legend and text online and in print. This error, which does not affect …

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

Teresa Niccoli, Melissa Cabecinha, Anna Tillmann, Fiona Kerr et autres

Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporters in both neurons and endothelial cells of the blood-brain barrier. However, whether increasing glucose transport into either …

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