Hrvoje Augustin

Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6 -associated neurodegeneration

Biqin Zhang, E. Dunn, Robin S. B. Williams, Stuart G. Snowden et autres

PLA2G6-associated neurodegeneration (PLAN) is a group of rare genetic disorders characterised by progressive neurodegeneration resulting from mutations in the PLA2G6 gene, encoding a calcium-independent phospholipase enzyme. Here, we have explored the effects of decanoic acid (DA), a medium-chain fatty acid, in the …

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Plum modulates Myoglianin and regulates synaptic function in D. melanogaster

Virender Kumar Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers et autres

Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β superfamily of growth factors, are powerful regulators …

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Medium-Chain Fatty Acids Rescue Motor Function and Neuromuscular Junction Degeneration in a Drosophila Model of Amyotrophic Lateral Sclerosis

E. Dunn, Joern R. Steinert, Aelfwin Stone, Virender Kumar Sahota et autres

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterised by progressive degeneration of the motor neurones. An expanded GGGGCC (G4C2) hexanucleotide repeat in C9orf72 is the most common genetic cause of ALS and frontotemporal dementia (FTD); therefore, the resulting disease is …

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Potential benefits of medium chain fatty acids in aging and neurodegenerative disease

E. Dunn, Biqin Zhang, Virender Kumar Sahota, Hrvoje Augustin

Neurodegenerative diseases are a large class of neurological disorders characterized by progressive dysfunction and death of neurones. Examples include Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Aging is the primary risk factor for neurodegeneration; individuals over 65 are more …

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Author response for "Plum modulates Myoglianin and regulates synaptic function in D. melanogaster"

Virender Kumar Sahota, Aelfwin Stone, Nathaniel S. Woodling, Jereme G. Spiers et autres

A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster

Hrvoje Augustin, Asaph Zylbertal, Linda Partridge

, usually in the face of a threatening visual stimulus. Two branches of the circuit promote the response by stimulating an escape jump followed by flight initiation. A recent work demonstrated an age-associated decline in the speed of signal propagation through the …

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Plum is a novel regulator of synaptic function and muscle size in D. melanogaster

Hrvoje Augustin, Jereme G. Spiers, Nathaniel S. Woodling, Joern R. Steinert et autres

ABSTRACT Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β superfamily of growth factors, are powerful …

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A computational model of the escape response latency in the Giant Fiber System of Drosophila melanogaster

Hrvoje Augustin, Asaph Zylbertal, Linda Partridge

ABSTRACT The Giant Fiber System (GFS) is a multi-component neuronal pathway mediating rapid escape response in the adult fruit-fly Drosophila melanogaster , usually in the face of a threatening visual stimulus. Two branches of the circuit promote the response by stimulating an …

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Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

Hrvoje Augustin, Kieran McGourty, Marcus J. Allen, Jennifer Adcott et autres

The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal …

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Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Hrvoje Augustin, Kieran McGourty, Marcus J. Allen, Sirisha Kudumala Madem et autres

Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the "insulin paradox").Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), a …

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Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies

Linda Partridge, Hrvoje Augustin, Jennifer Adcott, Fiona Kerr et autres

Lowered insulin/insulin-like growth factor (IGF) signaling (IIS) can extend healthy lifespan in worms, flies, and mice, but it can also have adverse effects (the “insulin paradox”). Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system (GFS), …

Complex roles of myoglianin in regulating adult performance and lifespan

Hrvoje Augustin, Jennifer Adcott, Christopher J. H. Elliott, Linda Partridge

Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modeling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects on the neuromuscular system, genetic manipulations of myoglianin expression levels …

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