Benjamin Aleyakpo

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

Dunxin Shen, Alec J. Vincent, Evan Udine, Yazead Buhidma et autres

Neurodegenerative diseases are characterized by the localized loss of neurons. Why cell death is triggered only in specific neuronal populations and whether it is the response to toxic insults or the initial cellular state that determines their vulnerability is unknown. To understand …

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Evidence for involvement of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis

Felix O’Farrell, Benjamin Aleyakpo, Rima Mustafa, Xiyun Jiang et autres

Biological pathways between alcohol consumption and alcohol liver disease (ALD) are not fully understood. We selected genes with known effect on (1) alcohol consumption, (2) liver function, and (3) gene expression. Expression of the orthologs of these genes in Caenorhabditis elegans and …

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A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models

Dongwei Xu, Alec J. Vincent, Andrés González‐Gutiérrez, Benjamin Aleyakpo et autres

Brains are highly metabolically active organs, consuming 20% of a person's energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation of insoluble protein deposits, it's …

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A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models

Dongwei Xu, Alec J. Vincent, Andrés González‐Gutiérrez, Benjamin Aleyakpo et autres

Abstract Brains are highly metabolically active organs, consuming 20% of an organisms’ energy at resting state. A decline in glucose metabolism is a common feature across a number of neurodegenerative diseases. Another common feature is the progressive accumulation of insoluble protein deposits, …

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Evidence for Involvement of the Alcohol Consumption WDPCP Gene in Lipid Metabolism, and Liver Cirrhosis

Raha Pazoki, Felix O’Farrel, Benjamin Aleyakpo, Rima Mustafa et autres

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Evidence for Involvement of WDPCP Gene in Alcohol Consumption, Lipid Metabolism, and Liver Cirrhosis

Felix O’Farrell, Benjamin Aleyakpo, Rima Mustafa, Xiyun Jiang et autres

Abstract Alcohol consumption continues to cause a significant health burden globally. The advent of genome-wide association studies has unraveled many genetic loci associated with alcohol consumption. However, the biological effect of these loci and the pathways involved in alcohol consumption and its …

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Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity

Teresa Niccoli, Fiona Kerr, Inge Snoeren, Daniel K. Fabian et autres

Abstract Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 42 toxicity, genes involved in the unfolded …

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Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system

Ekin Bolukbasi, Nathaniel S. Woodling, Dobril K. Ivanov, Jennifer Adcott et autres

Significance Aging is the main risk factor for the costliest diseases in today’s world. However, significant gaps remain in understanding how different cell types modulate this most common physiological process. Here, we use published single-cell gene expression data to map the prolongevity …

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PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity

Teresa Niccoli, Ziyu Ren, Nathaniel S. Woodling, Benjamin Aleyakpo et autres

Alzheimer's disease (AD) is the most common form of dementia and the most prevalent neurodegenerative disease. Genome-wide association studies have linked PICALM to AD risk. PICALM has been implicated in Aβ42 production and turnover, but whether it plays a direct role in …

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The neuronal receptor tyrosine kinase Alk is a target for longevity

Nathaniel S. Woodling, Benjamin Aleyakpo, Miranda C. Dyson, Lucy J. Minkley et autres

Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin-like growth factor receptor and its orthologues, extends healthy lifespan in organisms from diverse evolutionary taxa. This raises the possibility that other RTKs, including those already well studied for their roles …

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G-protein αq gene expression plays a role in alcohol tolerance in Drosophila melanogaster

Benjamin Aleyakpo, Oghenetega Umukoro, Ryan G. Kavlie, Daniel C. Ranson et autres

Ethanol is a psychoactive substance causing both short- and long-term behavioural changes in humans and animal models. We have used the fruit fly Drosophila melanogaster to investigate the effect of ethanol exposure on the expression of the Gαq protein subunit. Repetitive exposure …

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The Role of G Protein In Alcohol Related Behaviours Using Drosophila melanogaster As A Model

Benjamin Aleyakpo, Oghenetega Umokoro, Olivia Corcoran, Stefano O. Casalotti

Ethanol, classified as a drug, affects the central nervous system, and its consumption has been linked to the development of several behaviours including tolerance and dependence. Alcohol tolerance is defined as the need for higher doses of alcohol to induce the same …