Michiko Horiguchi

Void-Bearing Hierarchical Coacervates in the Decylammonium Bromide/Sodium Salicylate Vesicle-to-Coacervate Pathway

Shinichi Hata, Miya Urui, Nobutaka Numoto, Nobutsugu Hamamoto et autres

A longstanding challenge in surfactant assembly is accessing vesicle and condensed states in low-molecular-weight systems without precipitation or severe kinetic trapping while obtaining structural insights into the resulting mesostructures. Here, we show that a two-component mixture of decylammonium bromide (DeAB) and sodium …

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シアノコバラミン点眼液の医療用医薬品と一般用医薬品の比較

Kota Beppu, Yuya TSURUDOME, Michiko Horiguchi, Kentaro Ushijima

当研究室では以前に、タフルプロスト点眼液の先発医薬品と後発医薬品の製剤学的比較試験を実施し、点眼容器の使いやすさに違いがあることを報告した。今回は、同一企業が販売する医療用医薬と一般用医薬品について製剤学的比較試験を実施した。試験薬は、眼精疲労に対して一般的に用いられるシアノコバラミン点眼液とした。一般用医薬品の点眼液1 滴あたりの重量は、医療用医薬品よりも有意に大きかった。このため、一般用医薬品の点眼剤 1 本あたりの総滴下数（平均 108 滴）は、医療用医薬品（平均 116 滴）よりも有意に少なかった。一般用医薬品は防腐剤が含まれておらず、開栓後10 日間で使用することと明記されている。今回の検討において、一般用医薬品には通常回数使用した場合でも 10 日分は充填されていた。物理学的性質については、医療用医薬品と一般用医薬品で完全に一致するものは無かったが、pH や浸透圧比からいずれの製剤も使用時の不快感は小さいと推測される。以上より、シアノコバラミン点眼液を医療用医薬品から一般用医薬品に切換えても、使用感に大きな違いは生じないものと考えられる。

jp (code pays fourni par la source)

German Chamomile (Matricaria chamomilla) Induces Cytochrome P450 Expression Through Increased BMAL1 Protein Expression in Liver Nuclei

Yuya Tsurudome, Mai Enrin, Yukiyo Wada, Michiko Horiguchi et autres

German chamomile (Matricaria chamomilla) is a medicinal herb that promotes improved digestion and reduces insomnia. Although it is widely used worldwide, the mechanism of induction of drug-metabolizing enzymes is unknown. We found that German chamomile extracts induced cytochrome P450 expression at the …

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Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice

Yukiyo Wada, Kanako Ishihara, Yuya Tsurudome, Michiko Horiguchi et autres

Background: ATP-binding cassette (ABC) transporters are expressed in the vascular walls of brain capillaries and remove toxic chemicals from the brain. The expression of ABC transporters in peripheral organs is transcriptionally regulated by clock genes and exhibits 24 h periodic fluctuations. In …

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The Diurnal Variation in Mitochondrial Gene in Human Type 2 Diabetic Mesenchymal Stem Cell Grafts

Michiko Horiguchi, Ken-ichi Yoshihara, Yoichi Mizukami, Kenji Watanabe et autres

The application of regenerative therapy through stem cell transplantation has emerged as a promising avenue for the treatment of diabetes mellitus (DM). Transplanted tissue homeostasis is affected by disturbances in the clock genes of stem cells. The aim of this study is …

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Circadian Rhythms of Clock Genes After Transplantation of Mesenchymal Stem Cells with Type 2 Diabetes Mellitus

Michiko Horiguchi, Ken-ichi Yoshihara, Kenji Watanabe, Yuya Tsurudome et autres

Regenerative therapy involving stem cell transplantation has become an option for the radical treatment of diabetes mellitus. Disruption in the clock genes of stem cells affects the homeostasis of transplanted tissues. We examined the circadian rhythm of genes in transplanted adipose-derived mesenchymal …

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Increased SPARC in brain microvessels of ob/ob mice accelerates molecular transport into the brain accompany with albumin

Yuya Tsurudome, Yumi Takahata, Nao Morita, Soma Yamauchi et autres

Cytotoxic metabolites originating from the peripheral circulation can induce central nervous system complications associated with diabetes. Since a large proportion of these metabolites bind to plasma albumin, mechanisms for transporting albumin-metabolite complexes into the brain exist under diabetic conditions. Secreted protein acidic …

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Drug Delivery Strategies for Age-Related Diseases

Ken-ichi Yoshihara, Michiko Horiguchi

Drug delivery systems (DDSs) enable the controlled release of drugs in the body. DDSs have attracted increasing attention for the treatment of various disorders, including cancer, inflammatory diseases, and age-related diseases. With recent advancements in our understanding of the molecular mechanisms of …

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BRCA1 and 53BP1 regulate reprogramming efficiency by mediating DNA repair pathway choice at replication-associated double-strand breaks

Daniela Georgieva, Ning Wang, Angelo Taglialatela, Stepan Jerabek et autres

Reprogramming to pluripotency is associated with DNA damage and requires the functions of the BRCA1 tumor suppressor. Here, we leverage separation-of-function mutations in BRCA1/2 as well as the physical and/or genetic interactions between BRCA1 and its associated repair proteins to ascertain the …

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The circadian rhythms of mitochondrial function after transplantation of mesenchymal stem cells

Michiko Horiguchi, Yoichi Mizukami, Kenji Watanabe, Ken-ichi Yoshihara et autres

Abstract Regenerative therapy involving stem cell transplantation has become an option for the radical treatment of diabetes mellitus. Disruption in the clock genes of stem cells affects the homeostasis of transplanted tissues. This is possibly the first study to examine the circadian …

jp (code pays fourni par la source)

The circadian rhythm of gene expression in mesenchymal stem cells.

Michiko Horiguchi

The dataset for the results of next-generation sequencing in mesenchymal stem cells.

Inhibition of Tumor-Derived C-C Motif Chemokine Ligand 2 Expression Attenuates Tactile Allodynia in NCTC 2472 Fibrosarcoma-Inoculated Mice

Marie Taniguchi, Sai Yasukochi, Wakaba Yamakawa, Yuya Tsurudome et autres

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