Nao Morita

Increased SPARC in brain microvessels of ob/ob mice accelerates molecular transport into the brain accompany with albumin

Yuya Tsurudome, Yumi Takahata, Nao Morita, Soma Yamauchi et autres

Cytotoxic metabolites originating from the peripheral circulation can induce central nervous system complications associated with diabetes. Since a large proportion of these metabolites bind to plasma albumin, mechanisms for transporting albumin-metabolite complexes into the brain exist under diabetic conditions. Secreted protein acidic …

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Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice

Yuya Tsurudome, Nao Morita, Michiko Horiguchi, Kentaro Ushijima

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Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice

Yuya Tsurudome, Nao Morita, Michiko Horiguchi, Kentaro Ushijima

Abstract Diabetes patients are at a high risk of developing complications related to angiopathy and disruption of the signal transduction system. The liver is one of the multiple organs damaged during diabetes. Few studies have evaluated the morphological effects of adhesion factors …

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